{"id":"W896551578","doi":"10.1007/s00044-015-1411-z","title":"Anti-HIV activity of new pyrazolobenzothiazine 5,5-dioxide-based acetohydrazides","year":2015,"lang":"en","type":"article","venue":"Medicinal Chemistry Research","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; Higher Education Commission, Pakistan; University of Karachi","keywords":"Cytotoxicity; Chemistry; Vero cell; Human immunodeficiency virus (HIV); EC50; Stereochemistry; Combinatorial chemistry; In vitro; Virology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395583,0.0003241174,0.0002376076,0.0001749282,0.0001362648,0.0001356396,0.0004013547,0.0001523616,0.001810265],"category_scores_gemma":[0.0001014814,0.000102231,0.0001363257,0.0001578671,0.0001867423,0.0001396547,0.0001871352,0.0003182944,0.0003205488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001827825,"about_ca_system_score_gemma":0.0002064315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00094221,"about_ca_topic_score_gemma":0.001759525,"domain_scores_codex":[0.9999253,0.00001869502,0.000006105716,0.000008568221,0.0000155188,0.00002589084],"domain_scores_gemma":[0.9999658,0.000006214931,0.00000886225,0.000003420441,0.000005374996,0.00001038773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001001106,0.0001321732,0.0003667485,0.0003282715,0.00001881709,0.0004096408,0.00009274861,0.0009657901,0.9810166,0.0007462777,0.0004941335,0.01442774],"study_design_scores_gemma":[0.0002439259,0.002324565,0.00263397,0.00002158296,0.00004603855,0.0004944642,0.00005192282,0.001360103,0.9832759,0.00008138009,0.009444742,0.00002132486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849378,0.006025861,0.002177178,0.0002143303,0.00007734993,0.0000603822,0.0002806942,0.0001471965,0.006079218],"genre_scores_gemma":[0.9914361,0.003511533,0.001359217,0.00007258801,0.00003139509,0.0000288633,0.0002965959,0.00001011263,0.003253585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001810265,"threshold_uncertainty_score":0.006055892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1960989609690467,"score_gpt":0.3826843431325184,"score_spread":0.1865853821634717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}