{"id":"W899581155","doi":"10.1158/1538-7445.panca2014-a106","title":"Abstract A106: BRCA mutation sensitizes pancreatic tumors to treatment with cisplatin","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Gemcitabine; Cisplatin; PARP inhibitor; Medicine; Chemotherapy; BRCA mutation; Pancreatic cancer; In vivo; Cancer research; Internal medicine; Oncology; Cancer; DNA repair; Ovarian cancer; Poly ADP ribose polymerase; Biology; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001383058,0.0003597407,0.0004619999,0.0002635427,0.0001999791,0.000340007,0.0003092321,0.000445054,0.00415415],"category_scores_gemma":[0.0001401535,0.0001807178,0.0003120465,0.0002588185,0.0002804333,0.0001918869,0.0002505673,0.001102699,0.0008561874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003349475,"about_ca_system_score_gemma":0.0002908694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005564841,"about_ca_topic_score_gemma":0.0004921526,"domain_scores_codex":[0.9998908,0.00001716871,0.00001472666,0.00003034432,0.00002623241,0.00002069281],"domain_scores_gemma":[0.9998673,0.00003277318,0.00002220189,0.00002090388,0.000008397348,0.00004842891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002534935,0.0008916383,0.005856352,0.0001350523,0.00004857641,0.001812346,0.00003895081,0.0005158616,0.9800791,0.0001557814,0.001322643,0.006608754],"study_design_scores_gemma":[0.001047147,0.01610964,0.05545364,0.00002823881,0.0001349763,0.02251303,0.00008484349,0.003440603,0.8893118,0.0002010899,0.01165377,0.00002125204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993707,0.0007095579,0.0007669491,0.0002197133,0.00006584301,0.0001595069,0.001022316,0.0001136286,0.003235648],"genre_scores_gemma":[0.9935221,0.000610064,0.001477402,0.0001298131,0.00002848334,0.0001010497,0.001419472,0.00002610356,0.002685564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00415415,"threshold_uncertainty_score":0.013897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1541251158898055,"score_gpt":0.4606634936270426,"score_spread":0.3065383777372371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}