{"id":"W900130332","doi":"10.1016/j.cellsig.2015.07.006","title":"Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: Insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants","year":2015,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"G protein-coupled receptor; Adenylyl cyclase; Receptor; Dopamine receptor D2; Transmembrane domain; Dopamine receptor; Signal transduction; cAMP-dependent pathway; Cell biology; Gs alpha subunit; Dopaminergic; Biology; Mutant; G protein; Chemistry; Biochemistry; Dopamine; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004549713,0.0002127365,0.0004261188,0.0001638038,0.00004279679,0.00001474155,0.00007771051,0.0001937655,0.0000121155],"category_scores_gemma":[0.00004736225,0.0002080317,0.00005844765,0.0001550947,0.0002172096,0.00002490025,0.00002825748,0.0001212332,1.233634e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001033531,"about_ca_system_score_gemma":0.00009222385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000122575,"about_ca_topic_score_gemma":0.00003487827,"domain_scores_codex":[0.9983841,0.000179722,0.0006172195,0.0004375573,0.0002149855,0.0001663853],"domain_scores_gemma":[0.9992299,0.00008836259,0.0002854862,0.0001428898,0.0001438513,0.0001094881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001252042,0.00005752272,0.004550715,0.0001237772,0.00006695313,0.00001783055,0.0005716936,0.0003564736,0.9926004,0.00008131182,0.000003925021,0.0003173007],"study_design_scores_gemma":[0.00210351,0.0005009795,0.0003830442,0.0002866773,0.00005750766,0.00001721165,0.0009235987,0.0008618358,0.9941153,0.0005210757,0.00002435367,0.0002049133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709021,0.02043481,0.008320839,0.00002000961,0.00007479289,0.0002030811,0.00002597622,0.000005853655,0.0000125134],"genre_scores_gemma":[0.9972343,0.001236902,0.001284808,0.000008969937,0.0000771225,0.000006123978,0.00009379357,0.00002490919,0.00003301067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02633223,"threshold_uncertainty_score":0.8483287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03134118175197446,"score_gpt":0.2316544531406032,"score_spread":0.2003132713886288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}