{"id":"W900130332","doi":"10.1016/j.cellsig.2015.07.006","title":"Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: Insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants","year":2015,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"G protein-coupled receptor; Adenylyl cyclase; Receptor; Dopamine receptor D2; Transmembrane domain; Dopamine receptor; Signal transduction; cAMP-dependent pathway; Cell biology; Gs alpha subunit; Dopaminergic; Biology; Mutant; G protein; Chemistry; Biochemistry; Dopamine; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007851699,0.0003203218,0.0002135283,0.0001126984,0.0001068931,0.0001788185,0.0001749289,0.0003452402,0.0005838408],"category_scores_gemma":[0.0001007961,0.00008113884,0.0003109406,0.00008586683,0.0002027744,0.0001346599,0.0001434672,0.000398409,0.0001340712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002338284,"about_ca_system_score_gemma":0.0001642201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006604377,"about_ca_topic_score_gemma":0.0006059931,"domain_scores_codex":[0.9999256,0.00001437687,0.000008922059,0.00001500764,0.00002017545,0.00001595248],"domain_scores_gemma":[0.9999347,0.00001343559,0.00002428965,0.000004042649,0.000005062217,0.00001856348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001594077,0.00001323164,0.0002979349,0.00001623355,0.000003224739,0.0001029031,0.00001180706,0.0001139429,0.9987827,0.00005801264,0.000009765658,0.0004308632],"study_design_scores_gemma":[0.00004454454,0.0003925125,0.01309211,0.000009197205,0.00003368169,0.0009558065,0.00006366464,0.002303523,0.9818029,0.00005346043,0.001234754,0.00001384749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988048,0.0002464424,0.0005750295,0.00003194671,0.000006417891,0.000006569273,0.0001084672,0.000008712589,0.0002116697],"genre_scores_gemma":[0.9984323,0.0001657047,0.0009153085,0.00003685982,0.000003170279,0.000006687522,0.0001675477,0.000004937454,0.0002673141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006604377,"threshold_uncertainty_score":0.001953125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03134118175197446,"score_gpt":0.2316544531406032,"score_spread":0.2003132713886288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}