{"id":"W91596172","doi":"10.3233/ch-2010-1294","title":"The endothelial-protective effects of HMG-CoA reductase inhibition in the setting of ischemia and reperfusion injury","year":2010,"lang":"en","type":"article","venue":"Clinical Hemorheology and Microcirculation","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Heart and Stroke Foundation of Canada","keywords":"HMG-CoA reductase; Cardioprotection; Medicine; Reductase; Ischemia; Pharmacology; Reperfusion injury; Cyclooxygenase; Hydroxymethylglutaryl-CoA reductase; Endothelial dysfunction; Enzyme; Internal medicine; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001852799,0.0000869396,0.000250007,0.00004319769,0.0001038284,0.0000033307,0.00002952348,0.0002554623,0.000003000237],"category_scores_gemma":[0.001827766,0.00005245482,0.00005512008,0.00008589247,0.0004992979,0.00003971884,0.00003477349,0.0005291665,8.247422e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006107707,"about_ca_system_score_gemma":0.00004952021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000222708,"about_ca_topic_score_gemma":0.00002387299,"domain_scores_codex":[0.9988949,0.000276198,0.000446646,0.0001841733,0.00008002543,0.0001180314],"domain_scores_gemma":[0.9977564,0.001716673,0.0002350446,0.0001830799,0.00007228817,0.00003650477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004008878,0.00006125349,0.08307848,0.0002116875,0.00001280393,0.000008424465,0.000683276,1.857326e-7,0.8973532,0.0006544677,0.00004626601,0.0174891],"study_design_scores_gemma":[0.001868867,0.000388724,0.3313676,0.000155656,0.00007666452,0.0001452357,0.0001358838,0.0002477522,0.663799,0.001687523,0.00005959358,0.00006749435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982398,0.000263265,0.00004809859,0.0005279645,0.0002612709,0.000598352,0.000002059081,0.00000666141,0.00005251072],"genre_scores_gemma":[0.9994108,0.0001177363,0.0001164632,0.0001571425,0.0001555945,0.00002006326,0.000008234889,0.000006222722,0.000007733661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2482891,"threshold_uncertainty_score":0.2298995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005937245174299573,"score_gpt":0.3011379839406315,"score_spread":0.295200738766332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}