{"id":"W917798766","doi":"10.1096/fasebj.27.1_supplement.705.13","title":"The HDAC inhibitor, vorinastat, prevents TGF‐β1 induced EMT and apoptosis in human renal proximal tubular cells","year":2013,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; St Joseph's Health Care; McMaster University; University of Toronto; McMaster University Medical Centre","funders":"","keywords":"Epithelial–mesenchymal transition; Apoptosis; Transforming growth factor; Cancer research; Histone deacetylase inhibitor; Fibroblast; Chemistry; Cadherin; Vimentin; Cell biology; Endocrinology; Histone deacetylase; Internal medicine; Biology; Cell; Medicine; Histone; Cancer; In vitro; Immunohistochemistry; Biochemistry; Metastasis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001321439,0.0001731268,0.0004232748,0.0001843365,0.0001518983,0.0001619584,0.0001594611,0.0001574083,0.00119559],"category_scores_gemma":[0.00008515863,0.0001341014,0.0003300841,0.0001541589,0.000113973,0.0001248118,0.0001018623,0.0004611111,0.000210315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001587836,"about_ca_system_score_gemma":0.000248785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029622,"about_ca_topic_score_gemma":0.001916619,"domain_scores_codex":[0.9999028,0.00001603692,0.00001535839,0.00001401387,0.00002705884,0.00002463584],"domain_scores_gemma":[0.9999573,0.000009856909,0.000009609539,0.00000617563,0.000008275018,0.000008752264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007450117,0.0002045024,0.0004087618,0.0001180209,0.00002167959,0.00007952481,0.00004079844,0.00009114852,0.9931592,0.00005128787,0.0001772002,0.004902806],"study_design_scores_gemma":[0.0001197419,0.00266831,0.00763896,0.00001112681,0.00005307781,0.0003704988,0.00005863529,0.0009443338,0.9843081,0.00003096379,0.0037913,0.000005070318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879805,0.008638992,0.001132861,0.0001782635,0.00008167837,0.0000504029,0.0004064309,0.000097711,0.001432989],"genre_scores_gemma":[0.9918807,0.003626832,0.001175418,0.00007000081,0.00002094428,0.00004576663,0.0009198564,0.000008921988,0.002251509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00119559,"threshold_uncertainty_score":0.003999591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318756151416379,"score_gpt":0.2526943552313555,"score_spread":0.2395067937171917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}