{"id":"W918099573","doi":"10.1080/21645515.2015.1065363","title":"Sustained immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine administered as a two-dose schedule in adolescent girls: Five-year clinical data and modeling predictions from a randomized study","year":2015,"lang":"en","type":"article","venue":"Human Vaccines & Immunotherapeutics","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Quebec - Clinical Research Organization in Cancer; Centre hospitalier universitaire de Québec; University of Alberta","funders":"","keywords":"Immunogenicity; Medicine; Confidence interval; Vaccination; Randomized controlled trial; Reactogenicity; Post-hoc analysis; Cohort; HPV vaccines; Immunology; Vaccination schedule; Antibody titer; Geometric mean; Titer; Internal medicine; Antibody; HPV infection; Immunization; Cervical cancer; Cancer; Statistics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01223697,0.0005983879,0.001209656,0.0001963485,0.0001707109,0.0006204749,0.0007807368,0.0006834415,0.001416189],"category_scores_gemma":[0.005698003,0.0003330479,0.001916472,0.0001829691,0.0006181806,0.0004766317,0.0003936146,0.001150259,0.0002995555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006071606,"about_ca_system_score_gemma":0.001302824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009024063,"about_ca_topic_score_gemma":0.0006681335,"domain_scores_codex":[0.9977302,0.001684675,0.00009466844,0.0001996439,0.0001453182,0.0001454779],"domain_scores_gemma":[0.9963828,0.001668866,0.0009516335,0.0005479519,0.0001403178,0.0003083635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8210226,0.02881921,0.07324383,0.00059985,0.002309903,0.0001425483,0.0003953862,0.01471481,0.01088575,0.0006386448,0.0007926996,0.04643467],"study_design_scores_gemma":[0.1203543,0.7867196,0.05312872,0.00008306679,0.001927376,0.0001408786,0.000171739,0.0296626,0.005601726,0.0007104588,0.001453879,0.00004585236],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975056,0.0001784826,0.001135944,0.00004679281,0.00001246856,0.0006309414,0.0002637326,0.00001419542,0.0002118177],"genre_scores_gemma":[0.9973456,0.000197839,0.001122606,0.00004688791,0.00001692004,0.0005936518,0.0003751446,0.000006381406,0.0002951361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01223697,"threshold_uncertainty_score":0.06471604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2286029570257826,"score_gpt":0.458318295095581,"score_spread":0.2297153380697984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}