{"id":"W927468184","doi":"10.1007/s40262-015-0303-1","title":"A Critical Review of the Current Evidence for Measuring Drug Concentrations of First-Line Agents Used to Treat Tuberculosis in Children","year":2015,"lang":"en","type":"review","venue":"Clinical Pharmacokinetics","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Pyrazinamide; Tuberculosis; Ethambutol; Intensive care medicine; Drug; Dosing; Pharmacotherapy; Isoniazid; Adverse effect; Disease; Therapeutic drug monitoring; Psychological intervention; Rifapentine; Mycobacterium tuberculosis; Pharmacology; Latent tuberculosis; Internal medicine; Pathology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003795963,0.001162333,0.004073121,0.005049315,0.0003196714,0.001925417,0.001675674,0.001775017,0.003718116],"category_scores_gemma":[0.01112135,0.0006267044,0.002957477,0.004233121,0.0006955211,0.001938502,0.0009422406,0.001733893,0.0005482641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001404862,"about_ca_system_score_gemma":0.004892909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003318305,"about_ca_topic_score_gemma":0.007599656,"domain_scores_codex":[0.9980175,0.0005079387,0.0007709749,0.000188854,0.0004512407,0.00006338523],"domain_scores_gemma":[0.9912764,0.006423356,0.001277154,0.00009566489,0.0008239255,0.0001035559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000307672,0.00005899378,0.0005053666,0.525878,0.002284633,0.0002296103,0.0001567777,0.0002185492,0.0005676162,0.001556449,0.01644425,0.4517922],"study_design_scores_gemma":[0.0002107104,0.0003843828,0.004344072,0.4561813,0.01452029,0.001985799,0.0003221454,0.0001804556,0.0006192247,0.001880826,0.5192767,0.00009408905],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000495254,0.9995654,0.00003076026,0.0001670695,0.00006830518,0.000007726925,0.00002746831,0.000001386049,0.00008231433],"genre_scores_gemma":[0.0006223989,0.9987612,0.0001827957,0.0002791726,0.00007404776,0.00001182017,0.00002549551,8.06116e-7,0.00004226327],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005049315,"threshold_uncertainty_score":0.0200752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6292262917620522,"score_gpt":0.6064996879856832,"score_spread":0.02272660377636904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}