{"id":"W937127559","doi":"10.1016/j.bmcl.2015.07.093","title":"Recent progress on MAP kinase pathway inhibitors","year":2015,"lang":"en","type":"review","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"MAPK/ERK pathway; Signal transduction; Kinase; Anti-apoptotic Ras signalling cascade; Chemistry; Mitogen-activated protein kinase; Intracellular; Cancer research; Cell biology; Computational biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004703789,0.0009304096,0.001140466,0.001262085,0.0002143169,0.0007924187,0.0007187483,0.0006243022,0.00336555],"category_scores_gemma":[0.0005438161,0.000356994,0.0004234446,0.001375561,0.0003773812,0.001090948,0.0006718625,0.001818702,0.001453193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004754791,"about_ca_system_score_gemma":0.0006917327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004790542,"about_ca_topic_score_gemma":0.001346721,"domain_scores_codex":[0.9998643,0.00001997216,0.00001684027,0.00002758733,0.00004421495,0.00002701002],"domain_scores_gemma":[0.9998538,0.00006440413,0.00002707821,0.000005765047,0.00003016434,0.00001878648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002337875,0.0001499661,0.0001810646,0.01039681,0.0001079972,0.0002748099,0.00004940781,0.0007216659,0.006861879,0.00386477,0.02941065,0.9477472],"study_design_scores_gemma":[0.00009583719,0.000271766,0.0005844145,0.0009716884,0.0002416501,0.0007925313,0.00003285853,0.000329422,0.003593119,0.002028185,0.9910343,0.00002420813],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006399501,0.9953018,0.0006491782,0.0003582235,0.000362847,0.00001246637,0.00004569574,0.00002531856,0.002604451],"genre_scores_gemma":[0.003810271,0.9927301,0.0005118044,0.0005275615,0.0002658183,0.0000214638,0.00008304019,0.000004620377,0.002045377],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00336555,"threshold_uncertainty_score":0.0112589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03257826275852975,"score_gpt":0.2847047729781015,"score_spread":0.2521265102195717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}