{"id":"W943586937","doi":"","title":"Stable Knockdown of Optineurin Expression in RGC-5 Cells Using Short Hairpin RNA Sequences","year":2008,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Gene knockdown; Optineurin; Small hairpin RNA; Cell biology; RNA; Molecular biology; Biology; Genetics; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004001069,0.0005227492,0.0004461966,0.0003074143,0.0003948292,0.00056694,0.0005485224,0.0004950464,0.001766467],"category_scores_gemma":[0.0001627637,0.0002106445,0.0005549439,0.0002594243,0.0004691149,0.0003321277,0.0002806693,0.0009055932,0.0005409325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007061084,"about_ca_system_score_gemma":0.0003904412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001356629,"about_ca_topic_score_gemma":0.002907361,"domain_scores_codex":[0.9996459,0.00004206372,0.00006295182,0.00009673997,0.00008940929,0.00006289013],"domain_scores_gemma":[0.9997777,0.00006204682,0.00006275223,0.00003832654,0.00002301873,0.00003612834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006965839,0.00002213664,0.00007669134,0.00003701558,0.00001031244,0.00003588772,0.0000253875,0.00006886549,0.9986816,0.0002614843,0.00009887413,0.0006120478],"study_design_scores_gemma":[0.00002593632,0.00009909729,0.0009794221,0.000003472084,0.00002349925,0.00006417666,0.00001736357,0.0009137288,0.9954553,0.0000295126,0.002384136,0.000004297112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760119,0.001620548,0.01374489,0.0003893263,0.0003427184,0.0002082549,0.002730609,0.0005383558,0.004413356],"genre_scores_gemma":[0.9759745,0.0006074616,0.01273255,0.0001463783,0.00004075751,0.0002065562,0.001994534,0.0001112604,0.008186026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001766467,"threshold_uncertainty_score":0.005909443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06508963588789493,"score_gpt":0.3349433769814745,"score_spread":0.2698537410935796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}