{"id":"W943948987","doi":"","title":"In Vivo Model for Drug Delivery Testing: Multi-Parameter Ocular Phenotyping in a Memantine-Treated Mouse Model of Retinal Degeneration","year":2009,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"In vivo; Memantine; Retinal degeneration; Retinal; Drug delivery; Drug; Medicine; Pharmacology; Animal model; Ophthalmology; Neuroscience; Pathology; Biology; Chemistry; Internal medicine; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006600109,0.0002041375,0.0002344038,0.0002148283,0.0001019276,0.00001860643,0.0002897347,0.0001220538,0.00000201288],"category_scores_gemma":[0.0008297696,0.0002017935,0.00004833229,0.0004887157,0.000741664,0.0000434961,0.00008492604,0.0001002522,6.65441e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004401492,"about_ca_system_score_gemma":0.000400759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008008559,"about_ca_topic_score_gemma":0.00004296067,"domain_scores_codex":[0.9983212,0.00007458909,0.0003966427,0.000597987,0.0001726039,0.0004369417],"domain_scores_gemma":[0.9992869,0.0000400009,0.0001651685,0.0001549627,0.000253985,0.00009901649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001094029,0.0001350384,0.02370375,0.00001065619,0.000003550228,0.000004368002,0.0003997928,0.03203488,0.9434906,0.00004423903,0.00001482674,0.0000488697],"study_design_scores_gemma":[0.0004140555,0.0001219226,0.002093067,0.00001952457,0.000003520765,0.000004148037,0.0000364314,0.4475172,0.5482945,0.001361846,3.17406e-7,0.0001333545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980004,0.00005267104,0.00127294,0.0001193531,0.00002127583,0.0003926251,0.000008331567,0.000006892169,0.0001255218],"genre_scores_gemma":[0.9486415,0.000005244635,0.05076653,0.0002101717,0.00001116418,0.00004120941,0.0000160865,0.00001035669,0.0002977037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4154824,"threshold_uncertainty_score":0.82289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05091504207355407,"score_gpt":0.3194402990552315,"score_spread":0.2685252569816775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}