{"id":"W947311794","doi":"10.1182/blood.v124.21.3432.3432","title":"IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Gene knockdown; Cereblon; Downregulation and upregulation; Pomalidomide; Biology; Cell biology; Panobinostat; Cell growth; Cancer research; Cell culture; Ubiquitin ligase; Molecular biology; Lenalidomide; Immunology; Histone deacetylase; Histone; Ubiquitin; Multiple myeloma; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004789,0.0002648828,0.0002519764,0.0001800536,0.0001033787,0.0002910596,0.0001233401,0.000204115,0.001223716],"category_scores_gemma":[0.00004761453,0.00008304985,0.0002918655,0.000117805,0.0001453856,0.0001351046,0.0001086145,0.0004316938,0.0003727903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000257822,"about_ca_system_score_gemma":0.00008386782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002203551,"about_ca_topic_score_gemma":0.0002886769,"domain_scores_codex":[0.9998913,0.00001584682,0.00001168451,0.00002360935,0.00002845086,0.00002910285],"domain_scores_gemma":[0.999945,0.000005619358,0.00002364198,0.000006381993,0.000007252071,0.00001208346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009279724,0.00001333048,0.0001721965,0.00002350658,0.000001965674,0.00002214785,0.000005232047,0.0000169981,0.9990618,0.00002348352,0.00001861777,0.0005480034],"study_design_scores_gemma":[0.00001246241,0.0002894883,0.006166799,0.000003758983,0.00001213945,0.000167082,0.00002774579,0.00035026,0.9908577,0.00001465533,0.002095831,0.000002055294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992991,0.003195316,0.001712877,0.00009789589,0.00004216168,0.00004504523,0.0005765228,0.0000902612,0.001249037],"genre_scores_gemma":[0.9940055,0.001046172,0.001725755,0.00005947534,0.00001454701,0.00004283999,0.0006947076,0.00001238873,0.002398529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223716,"threshold_uncertainty_score":0.004093707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02027836385728962,"score_gpt":0.2407211620336887,"score_spread":0.2204427981763991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}