{"id":"W970458262","doi":"","title":"Targeted Sirna-Mediated Knockdown of Pro-Apoptotic Genes Delays Adult Retinal Ganglion Cell Death in vivo","year":2009,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Gene knockdown; Retinal ganglion cell; In vivo; Apoptosis; Cell biology; Programmed cell death; Retinal; Gene; Biology; Gene silencing; Cancer research; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002784437,0.0004788287,0.0004944399,0.0004706602,0.0002612852,0.000652921,0.0004805267,0.0005655934,0.001902211],"category_scores_gemma":[0.0002140283,0.000401615,0.0003923296,0.0002030307,0.000438412,0.0004776403,0.0001998253,0.001363198,0.0007568215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007974747,"about_ca_system_score_gemma":0.0006312663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001365115,"about_ca_topic_score_gemma":0.003178356,"domain_scores_codex":[0.9997513,0.00001968112,0.00003420293,0.00006502985,0.00006550108,0.00006429964],"domain_scores_gemma":[0.999616,0.0001044816,0.0001008001,0.00004186553,0.00003545884,0.000101254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000958108,0.00001891554,0.00005507437,0.00002335621,0.000006319925,0.00003419573,0.00001293709,0.00003683852,0.9989522,0.0001361077,0.00005727086,0.000570914],"study_design_scores_gemma":[0.00002572802,0.0001275464,0.001378826,0.00000467383,0.00002045407,0.0001062324,0.00002181929,0.0007504126,0.9965436,0.00004673806,0.0009704715,0.000003569382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815959,0.002919506,0.01062305,0.0003920124,0.0002014772,0.00005678743,0.001039522,0.0004653579,0.002706365],"genre_scores_gemma":[0.9811367,0.001807006,0.006813046,0.0002086144,0.0000358677,0.0000810123,0.0009438662,0.0001599547,0.008813764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001902211,"threshold_uncertainty_score":0.006363571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0169095596396049,"score_gpt":0.2842283062451613,"score_spread":0.2673187466055564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}