{"id":"W977409017","doi":"10.1096/fj.14-264796","title":"ATP‐binding cassette transporters and sterol <i>O</i> ‐acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification","year":2015,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Austrian Science Fund; University of Notre Dame; American Health Assistance Foundation; Ara Parseghian Medical Research Foundation; Ontario Genomics Institute; Canadian Institutes of Health Research; Ellison Medical Foundation; American Heart Association; Cystic Fibrosis Foundation; Heart and Stroke Foundation of Canada; U.S. Department of Defense","keywords":"Sterol; Sterol O-acyltransferase; Biochemistry; ATP-binding cassette transporter; Acyltransferases; Transporter; Acyltransferase; Squalene monooxygenase; Chemistry; Sterol regulatory element-binding protein; Cholesterol; Biology; Enzyme; Biosynthesis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006696417,0.000254519,0.000397999,0.0001528881,0.000215664,0.0001429622,0.0001293092,0.00006999,0.00002788055],"category_scores_gemma":[0.00002430714,0.0001697424,0.00008826502,0.000110967,0.00009651689,0.0002665309,0.0000327425,0.0003708343,0.00001701692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007141977,"about_ca_system_score_gemma":0.00004605652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002673136,"about_ca_topic_score_gemma":0.00004322858,"domain_scores_codex":[0.9984813,0.0001086535,0.0004616036,0.000280306,0.0003237134,0.0003444276],"domain_scores_gemma":[0.9988286,0.00005169688,0.0001180717,0.0002826032,0.00008104965,0.0006380003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001235971,0.00005620703,0.00869763,0.00004659762,0.0001164205,0.00009115773,0.01194318,0.00002771698,0.9658318,0.000004282012,0.0002638113,0.0116852],"study_design_scores_gemma":[0.02291205,0.001795436,0.3640072,0.001242286,0.001888219,0.02731719,0.004947151,0.0006921727,0.5041667,0.00005295697,0.06992832,0.001050281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917755,0.0004598521,0.0004974714,0.006193405,0.0004762343,0.000433822,0.00004416823,0.00003065902,0.00008889863],"genre_scores_gemma":[0.9955391,0.0003161071,0.0002989265,0.002815334,0.0004269125,0.000008437918,0.00001907686,0.00003913517,0.0005370026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4616651,"threshold_uncertainty_score":0.6921893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03410501246571763,"score_gpt":0.2665822543695157,"score_spread":0.2324772419037981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}