{"id":"W982200931","doi":"","title":"Light Activation of Rhodopsin Mutants T4K and T17M Causes Retinal Degeneration Due to Loss of Structural Integrity","year":2009,"lang":"en","type":"article","venue":"","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Rhodopsin; Degeneration (medical); Retinal degeneration; Mutant; Retinal; Structural integrity; Cell biology; Ophthalmology; Chemistry; Biology; Medicine; Biochemistry; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002242838,0.00077959,0.0004922053,0.0005223802,0.0003474321,0.0004635113,0.0009254162,0.0007754387,0.003336248],"category_scores_gemma":[0.0002837976,0.0004334327,0.0008634364,0.0003392407,0.0008107001,0.0003228561,0.0005188517,0.001434423,0.001162005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008760982,"about_ca_system_score_gemma":0.0007524732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004107081,"about_ca_topic_score_gemma":0.002702469,"domain_scores_codex":[0.9996258,0.00003968591,0.00006598231,0.00005808664,0.00008307547,0.0001273582],"domain_scores_gemma":[0.9993457,0.0001097536,0.0002387456,0.00007296447,0.00004065828,0.000192176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004994023,0.00003900004,0.0001359596,0.00002898087,0.00001431667,0.0001881615,0.00001896021,0.00007006883,0.9985039,0.0001493584,0.00005083746,0.000300954],"study_design_scores_gemma":[0.00005936431,0.0001915154,0.001958558,0.000009713192,0.000029403,0.0003975424,0.00005480132,0.0006327949,0.99575,0.00009458457,0.0008103386,0.00001137068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975275,0.0002941676,0.0006408795,0.0001147843,0.00004971673,0.00002363914,0.0005248367,0.00006724993,0.0007572287],"genre_scores_gemma":[0.9937004,0.0003325631,0.001300025,0.00008450315,0.00001465093,0.00005405942,0.0006040765,0.0001524954,0.003757236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004107081,"threshold_uncertainty_score":0.01116085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05294987621208959,"score_gpt":0.3443858301226821,"score_spread":0.2914359539105925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}