{"id":"W989925910","doi":"10.1371/journal.pone.0128244","title":"Swertisin an Anti-Diabetic Compound Facilitate Islet Neogenesis from Pancreatic Stem/Progenitor Cells via p-38 MAP Kinase-SMAD Pathway: An In-Vitro and In-Vivo Study","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Department of Biotechnology, Ministry of Science and Technology, India; Université Laval; Shastri Indo-Canadian Institute","keywords":"Neogenesis; Cell biology; SMAD; Progenitor cell; Biology; Stem cell; Islet; Cellular differentiation; MAPK/ERK pathway; Chemistry; Kinase; Signal transduction; Endocrinology; Insulin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127585,0.0003235176,0.0002149986,0.0002313299,0.0000887908,0.0001241695,0.0001174879,0.0001537524,0.001509416],"category_scores_gemma":[0.00005165753,0.0001021766,0.0003386416,0.0001010103,0.0001235542,0.0001798352,0.0001103557,0.0005556146,0.0002072144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001079686,"about_ca_system_score_gemma":0.0001204682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001578033,"about_ca_topic_score_gemma":0.0004021061,"domain_scores_codex":[0.9999555,0.000006949788,0.000005423393,0.000008128342,0.0000141168,0.000009944466],"domain_scores_gemma":[0.9999622,0.000006414705,0.00001149481,0.000003556666,0.000004926667,0.00001143402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001458171,0.0001084014,0.000070184,0.00008721338,0.000005846494,0.00005385609,0.00001173798,0.00004651638,0.9978452,0.00003861653,0.00002141953,0.001565189],"study_design_scores_gemma":[0.00002561396,0.001160331,0.001498047,0.000007208062,0.00002175422,0.0001205873,0.00001764165,0.0002187278,0.9955701,0.00002090734,0.001336972,0.000002185285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923972,0.003351874,0.001608616,0.0001138785,0.00004120597,0.00005542692,0.0003006435,0.00004415973,0.002086958],"genre_scores_gemma":[0.9878284,0.00489983,0.002256169,0.0000879072,0.00002570576,0.00005951423,0.0004912965,0.00001423134,0.004336991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001509416,"threshold_uncertainty_score":0.005049527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0697661126672853,"score_gpt":0.240972654693292,"score_spread":0.1712065420260067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}