{"id":"W992317070","doi":"10.1182/blood-2015-03-635151","title":"Cladribine and cytarabine in refractory multisystem Langerhans cell histiocytosis: results of an international phase 2 study","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Association Histiocytose France","keywords":"Cladribine; Medicine; Cytarabine; Internal medicine; Gastroenterology; Cytopenia; Refractory (planetary science); Langerhans cell histiocytosis; Toxicity; Surgery; Chemotherapy; Disease; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001897027,0.0001016847,0.0002428096,0.0001253415,0.00001239077,0.000006050021,0.00005720227,0.00004397118,0.000008709281],"category_scores_gemma":[0.00008810948,0.00008611467,0.00001986177,0.00008227645,0.00002616143,0.00007872566,0.00002154722,0.00006914992,0.000006435337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006315835,"about_ca_system_score_gemma":0.00006838518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006411762,"about_ca_topic_score_gemma":0.0002280131,"domain_scores_codex":[0.9991058,0.00004375276,0.0003058715,0.0002218797,0.0002221463,0.0001005369],"domain_scores_gemma":[0.9994487,0.00001987695,0.0000953214,0.0002197591,0.00008653626,0.0001298432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.011044,0.2321472,0.6871173,0.0003406428,0.0009893576,0.003866801,0.025582,0.00002983416,0.01243689,0.0000399568,0.001041612,0.02536434],"study_design_scores_gemma":[0.7119953,0.02800446,0.2250775,0.0005521086,0.001495065,0.0001963472,0.01063233,0.00181914,0.009184344,0.00003528195,0.01040644,0.0006016254],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945344,0.0003135157,0.000003415737,0.00005539396,0.00008816581,0.0004074811,0.00008043661,0.00002156103,0.004495668],"genre_scores_gemma":[0.9988085,0.00002105116,0.0003296813,0.0000170525,0.00004741029,0.00002281302,0.0001248548,0.00001206445,0.0006165848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7009513,"threshold_uncertainty_score":0.3511654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03326927811821148,"score_gpt":0.3170181235733548,"score_spread":0.2837488454551433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}