{"id":"W992317070","doi":"10.1182/blood-2015-03-635151","title":"Cladribine and cytarabine in refractory multisystem Langerhans cell histiocytosis: results of an international phase 2 study","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Association Histiocytose France","keywords":"Cladribine; Medicine; Cytarabine; Internal medicine; Gastroenterology; Cytopenia; Refractory (planetary science); Langerhans cell histiocytosis; Toxicity; Surgery; Chemotherapy; Disease; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002079833,0.0008145102,0.001174156,0.0002506824,0.0001937116,0.0005533804,0.0005018337,0.0006513604,0.001155214],"category_scores_gemma":[0.0009899079,0.0002474085,0.000727194,0.0002971692,0.0005539641,0.0004093649,0.0002277363,0.001192137,0.0002731789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006038809,"about_ca_system_score_gemma":0.0006749555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005628848,"about_ca_topic_score_gemma":0.001273563,"domain_scores_codex":[0.9991373,0.0005995755,0.00004078594,0.0000677572,0.00005977043,0.00009478115],"domain_scores_gemma":[0.9991499,0.0002185251,0.0001427177,0.00008809841,0.00004558853,0.0003551657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4682814,0.05321989,0.02194606,0.00152338,0.00258161,0.0006585025,0.0006926441,0.005454017,0.09642354,0.0004736018,0.003946763,0.3447986],"study_design_scores_gemma":[0.327611,0.5851776,0.05535242,0.0001651451,0.001208071,0.001446684,0.0001297246,0.002977142,0.01278031,0.000223033,0.01286602,0.00006294218],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904128,0.006457504,0.00040123,0.0002599987,0.00006405461,0.0004426517,0.000260053,0.00003603391,0.001665649],"genre_scores_gemma":[0.9913795,0.004123068,0.001207424,0.0005710067,0.00016766,0.000584659,0.001102372,0.00001848705,0.0008458338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002079833,"threshold_uncertainty_score":0.01099932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03326927811821148,"score_gpt":0.3170181235733548,"score_spread":0.2837488454551433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}