{"id":"W99745469","doi":"10.1055/s-2004-825634","title":"Preclinical Animal Models for Hemophilia Gene Therapy: Predictive Value and Limitations","year":2004,"lang":"en","type":"review","venue":"Seminars in Thrombosis and Hemostasis","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Factor IX; Medicine; Transgene; Vectors in gene therapy; Bioinformatics; Animal model; Gene; Vector (molecular biology); Immunology; Computational biology; Biology; Genetics; Internal medicine; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006547979,0.000504796,0.001103841,0.0001572897,0.0001715699,0.00006385423,0.0002861902,0.0006912546,0.000005851883],"category_scores_gemma":[0.0001401129,0.000452482,0.0003341677,0.0002030165,0.0003065534,0.00001249273,0.0002107021,0.0003182041,0.000001280804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007956044,"about_ca_system_score_gemma":0.0004458746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001021409,"about_ca_topic_score_gemma":0.00003678321,"domain_scores_codex":[0.9974836,0.000209876,0.0006062972,0.001008135,0.0002116315,0.0004805204],"domain_scores_gemma":[0.9987387,0.0002973664,0.0001900324,0.0004938198,0.0001045634,0.0001755236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007566144,0.000321569,0.00002518725,0.002519626,0.0006224027,0.000002291026,0.0002453298,0.00006256273,0.000976081,0.0001555043,0.0005266785,0.9937862],"study_design_scores_gemma":[0.008567533,0.04224763,0.0002232328,0.01998546,0.001984279,0.0001234103,0.0004883844,0.001276586,0.01636238,0.01066332,0.8940154,0.00406241],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01003359,0.987056,0.0001361109,0.0001641699,0.00006240197,0.001821808,0.0005957196,0.00001431494,0.0001159156],"genre_scores_gemma":[0.002181227,0.993734,0.002474215,0.0001148904,0.0001669102,0.0006197095,0.0005412703,0.0001097227,0.00005804834],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9897237,"threshold_uncertainty_score":0.9997927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1582882719071114,"score_gpt":0.4142927850259932,"score_spread":0.2560045131188818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}