Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
2010· article· en· Cell· Medicine
affno abstract
1,204
citations
Works
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314 workspage 1 of 13
Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695
2001· article· en· Journal of Biological Chemistry· Medicine
aff
954
citations
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
2000· article· en· Nature· Biochemistry, Genetics and Molecular Biology
affno abstract
904
citations
Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease
2002· article· en· Science· Medicine
aff
529
citations
γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?
2002· review· en· Nature reviews. Neuroscience· Medicine
afffundno abstract
509
citations
Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment
2004· article· en· Journal of Clinical Investigation· Medicine
fundno aff
429
citations
Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1
2000· article· en· Nature Cell Biology· Medicine
affno abstract
409
citations
Binding of the Positron Emission Tomography Tracer Pittsburgh Compound-B Reflects the Amount of Amyloid-β in Alzheimer's Disease Brain But Not in Transgenic Mouse Brain
2005· article· en· Journal of Neuroscience· Medicine
aff
376
citations
Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease
2004· article· en· Journal of Neuroscience· Medicine
fundno aff
348
citations
Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP
2005· article· en· Neuron· Medicine
affno abstract
334
citations
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ
2019· article· en· Neuron· Medicine
fundno affno abstract
332
citations
Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons
2000· article· en· Journal of Biological Chemistry· Neuroscience
aff
319
citations
Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type
2001· review· en· Brain Research Reviews· Medicine
affno abstract
313
citations
Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease
2006· article· en· Nature Neuroscience· Medicine
affno abstract
309
citations
Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane
2003· article· en· Journal of Biological Chemistry· Medicine
afffund
309
citations
Amyloid-β Deposits Lead to Retinal Degeneration in a Mouse Model of Alzheimer Disease
2008· article· en· Investigative Ophthalmology & Visual Science· Medicine
afffund
308
citations
TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity
2006· article· en· Nature· Medicine
affno abstract
297
citations
Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model
2010· article· en· Journal of Neuroscience· Medicine
fundno aff
275
citations
Molecular genetics of Alzheimer’s disease
2000· article· en· Biological Psychiatry· Medicine
affno abstract
270
citations
Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta
2013· article· en· Cell Reports· Neuroscience
afffund
250
citations
AMPA receptor downscaling at the onset of Alzheimer’s disease pathology in double knockin mice
2006· article· en· Proceedings of the National Academy of Sciences· Neuroscience
fundno aff
226
citations
Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain
2001· article· en· Brain Research· Medicine
affno abstract
219
citations
Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP
2008· article· en· Neurobiology of Aging· Medicine
afffundno abstract
219
citations
Early-Onset Familial Alzheimer's Disease (EOFAD)
2012· review· en· Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques· Medicine
afffundvenue
218
citations
Molecular biology and genetics of Alzheimer's disease
2005· review· en· Comptes Rendus Biologies· Medicine
aff
208
citations