Body Mass Index, Serum Sex Hormones, and Breast Cancer Risk in Postmenopausal Women
Pourquoi ce travail est-il dans la base ?
Une base qui oublie comment elle a trouvé un travail ne peut pas être vérifiée. Voici les voies qui ont admis celui-ci.
Aucune affiliation canadienne. Une base fondée sur la seule affiliation (le devis habituel) n'aurait jamais vu ce travail. C'est l'un des travaux qui justifient l'inversion de la base.
Résumé
Background: Obesity is associated with increased breast cancer risk among postmenopausal women. We examined whether this association could be explained by the relationship of body mass index (BMI) with serum sex hormone concentrations. Methods: We analyzed individual data from eight prospective studies of postmenopausal women. Data on BMI and prediagnostic estradiol levels were available for 624 case subjects and 1669 control subjects; data on the other sex hormones were available for fewer subjects. The relative risks (RRs) with 95% confidence intervals (CIs) of breast cancer associated with increasing BMI were estimated by conditional logistic regression on case-control sets, matched within each study for age and recruitment date, and adjusted for parity. All statistical tests were two-sided. Results: Breast cancer risk increased with increasing BMI (P trend = .002), and this increase in RR was substantially reduced by adjustment for serum estrogen concentrations. Adjusting for free estradiol reduced the RR for breast cancer associated with a 5 kg/m 2 increase in BMI from 1.19 (95% CI = 1.05 to 1.34) to 1.02 (95% CI = 0.89 to 1.17). The increased risk was also substantially reduced after adjusting for other estrogens (total estradiol, non-sex hormone-binding globulin-bound estradiol, estrone, and estrone sulfate), and moderately reduced after adjusting for sex hormonebinding globulin, whereas adjustment for the androgens (androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, and testosterone) had little effect on the excess risk. Conclusion: The results are compatible with the hypothesis that the increase in breast cancer risk with increasing BMI among postmenopausal women is largely the result of the associated increase in estrogens, particularly bioavailable estradiol. [J Natl Cancer From a recent meta-analysis, it was estimated that there is a 3% increase in risk per 1 kg/m 2 increase in BMI (3). The mechanism for the association between obesity and breast cancer risk is not established, but it may result, at least in part, from an increase in the serum concentration of bioavailable estradiol, which results in turn from both an increase in the production of estrogens by aromatase in the adipose tissue and a decrease in the serum concentration of sex hormone-binding globulin (SHBG) (4,5).
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
La notice
- Revue
- JNCI Journal of the National Cancer Institute
- Thématique
- Cancer Risks and Factors
- Domaine
- Medicine
- Établissements canadiens
- —
- Organismes subventionnaires
- University at BuffaloUniversity of California, San FranciscoDivision of Cancer Epidemiology and Genetics, National Cancer InstituteSchool of Medicine, New York UniversityUniversity of OxfordYork UniversityUniversity of Southern CaliforniaUniversity of ConnecticutKagoshima UniversityNational Cancer InstituteBrigham and Women's HospitalUniversity of MissouriUniversity of PittsburghJohns Hopkins University
- Mots-clés
- EstroneDehydroepiandrosterone sulfateBreast cancerSex hormone-binding globulinBody mass indexMedicineInternal medicineEstrone sulfateEndocrinologyEstrogenAndrostenedioneHormoneTestosterone (patch)CancerAndrogen
- Résumé présent dans OpenAlex
- oui