Exercise Increases Mitochondrial PGC-1α Content and Promotes Nuclear-Mitochondrial Cross-talk to Coordinate Mitochondrial Biogenesis
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Dossier post-publication
- Nature
- Retraction
- Motif
- Concerns/Issues about Data;Duplication of/in Image;Manipulation of Images;Original Data and/or Images not Provided and/or not Available;Upgrade/Update of Prior Notice(s);
- Date
- 11/23/2020 0:00
- Signalé par OpenAlex ?
- Oui
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Résumé
Endurance exercise is known to induce metabolic adaptations in skeletal muscle via activation of the transcriptional co-activator peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α). PGC-1α regulates mitochondrial biogenesis via regulating transcription of nuclear-encoded mitochondrial genes. Recently, PGC-1α has been shown to reside in mitochondria; however, the physiological consequences of mitochondrial PGC-1α remain unknown. We sought to delineate if an acute bout of endurance exercise can mediate an increase in mitochondrial PGC-1α content where it may co-activate mitochondrial transcription factor A to promote mtDNA transcription. C57Bl/6J mice (n = 12/group; ♀ = ♂) were randomly assigned to sedentary (SED), forced-endurance (END) exercise (15 m/min for 90 min), or forced endurance +3 h of recovery (END+3h) group. The END group was sacrificed immediately after exercise, whereas the SED and END+3h groups were euthanized 3 h after acute exercise. Acute exercise coordinately increased the mRNA expression of nuclear and mitochondrial DNA-encoded mitochondrial transcripts. Nuclear and mitochondrial abundance of PGC-1α in END and END+3h groups was significantly higher versus SED mice. In mitochondria, PGC-1α is in a complex with mitochondrial transcription factor A at mtDNA D-loop, and this interaction was positively modulated by exercise, similar to the increased binding of PGC-1α at the NRF-1 promoter. We conclude that in response to acute altered energy demands, PGC-1α re-localizes into nuclear and mitochondrial compartments where it functions as a transcriptional co-activator for both nuclear and mitochondrial DNA transcription factors. These results suggest that PGC-1α may dynamically facilitate nuclear-mitochondrial DNA cross-talk to promote net mitochondrial biogenesis.
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La notice
- Revue
- Journal of Biological Chemistry
- Thématique
- Adipose Tissue and Metabolism
- Domaine
- Medicine
- Établissements canadiens
- McMaster University
- Organismes subventionnaires
- Natural Sciences and Engineering Research Council of CanadaCanadian Institutes of Health ResearchMcMaster University
- Mots-clés
- Mitochondrial biogenesisMitochondrial DNAMitochondrionActivator (genetics)TFAMBiologyTranscription factorTranscription (linguistics)Cell biologyMolecular biologyGeneGenetics
- Résumé présent dans OpenAlex
- oui