[Retraction]MicroRNA-134 Promotes the Development of Atherosclerosis Via the ANGPTL4/LPL Pathway in Apolipoprotein E Knockout Mice
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Dossier post-publication
- Nature
- Retraction
- Motif
- Error in Data;Error in Image;
- Date
- 10/5/2021 0:00
- Signalé par OpenAlex ?
- Oui
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Résumé
AIMS: Atherosclerosis is the most common cause of cardiovascular disease, such as myocardial infarction and stroke. Previous study revealed that microRNA (miR)-134 promotes lipid accumulation and proinflammatory cytokine secretion through angiopoietin-like 4 (ANGPTL4)/lipid lipoprotein (LPL) signaling in THP-1 macrophages. METHODS: ApoE KO male mice on a C57BL/6 background were fed a high-fat/high-cholesterol Western diet, from 8 to 16 weeks of age. Mice were divided into four groups, and received a tail vein injection of miR-134 agomir, miR-134 antagomir, or one of the corresponding controls, respectively, once every 2 weeks after starting the Western diet. After 8 weeks we measured aortic atherosclerosis, LPL Activity, mRNA and protein levels of ANGPTL4 and LPL, LPL/ low-density lipoprotein receptor related protein 1 Complex Formation, proinflammatory cytokine secretion and lipid levels. RESULTS: Despite this finding, the influence of miR-134 on atherosclerosis in vivo remains to be determined. Using the well-characterized mouse atherosclerosis model of apolipoprotein E knockout, we found that systemic delivery of miR-134 agomir markedly enhanced the atherosclerotic lesion size, together with a significant increase in proinflammatory cytokine secretion and peritoneal macrophages lipid contents. Moreover, overexpression of miR-134 decreased ANGPTL4 expression but increased LPL expression and activity in both aortic tissues and peritoneal macrophages, which was accompanied by increased formation of LPL/low-density lipoprotein receptor-related protein 1 complexes in peritoneal macrophages. However, an opposite effect was observed in response to miR-134 antagomir. CONCLUSIONS: These findings suggest that miR-134 accelerates atherogenesis by promoting lipid accumulation and proinflammatory cytokine secretion via the ANGPTL4/LPL pathway. Therefore, targeting miR-134 may offer a promising strategy for the prevention and treatment of atherosclerotic cardiovascular disease.
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La notice
- Revue
- Journal of Atherosclerosis and Thrombosis
- Thématique
- Lipid metabolism and disorders
- Domaine
- Medicine
- Établissements canadiens
- Libin Cardiovascular Institute of AlbertaUniversity of Calgary
- Organismes subventionnaires
- Construct Program of the Key Discipline in Hunan ProvinceHunan Province Cooperative Innovation Center for Molecular Target New Drug StudyUniversity of South ChinaNational Natural Science Foundation of China
- Mots-clés
- Apolipoprotein EANGPTL4microRNAKnockout mouseApolipoprotein BMedicineInternal medicineBiologyGeneticsGeneCholesterolReceptor
- Résumé présent dans OpenAlex
- oui