Transfusion-Related Acute Lung Injury In A Paediatric Intensive Care Unit Of Pakistan.
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Cohort study of transfusion-related lung injury in a Pakistani PICU; a clinical epidemiology question.
This studies transfusion-related lung injury in children, not research itself.
Clinical cohort study of TRALI incidence in a Pakistani PICU; transfusion medicine outcomes.
Résumé
BACKGROUND: Transfusion-Related Acute Lung Injury (TRALI) is a major cause of transfusionrelated morbidity and mortality in the intensive care unit setting. There is a paucity of such data from Pakistan. The purpose of this study is to assess the incidence and outcome of TRALI in critically ill children admitted in a pediatric intensive care unit (PICU) of Pakistan. METHODS: This is a retrospective cohort study of all critically ill or injured children who developed TRALI or "possible" TRALI after blood transfusion based on Canadian Conference Consensus criteria in a closed multidisciplinary-cardiothoracic PICU from January 2012 to June 2016. The demographic, pertinent clinical data, transfusion-related variables and outcome of all cases of TRALI were recorded. RESULTS: Of total 2975 admissions in the PICU during study period, 35.8% (1066) received 5124 blood components. Eleven cases developed TRALI in our cohort. The incidence of TRALI was 1.03% per patient transfused and 0.19% (19/100,000 per blood product transfused). Median age was 8 (range 1-14) yr., 70 % (n=8) were male. Mean PRISM-III score was 16.3±6.7. Mean time interval for onset of TRALI was 2.73±1.67 hr. The postoperative cardiac surgical and hematology-oncology patients were most common categories (63.6%). Plasma and platelets were the most commomly identified trigger of TRALI. The case-specific mortality was 63.6% and the overall mortality was 10.7% (p<0.0001). CONCLUSIONS: The incidence of TRALI in critically ill children is low, but is associated with high mortality. Critically ill children with high PRISM-III score, postoperative cardiac surgical and hematology-oncology patients are often affected by TRALI.
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La notice
- Revue
- PubMed
- Thématique
- Blood transfusion and management
- Domaine
- Medicine
- Établissements canadiens
- —
- Organismes subventionnaires
- —
- Mots-clés
- MedicineIncidence (geometry)Pediatric intensive care unitIntensive care unitBlood productRetrospective cohort studyCohortTransfusion-related acute lung injuryBlood transfusionCohort studyPediatricsGuidelineIntensive care medicineEmergency medicineInternal medicineLungSurgeryPulmonary edema
- Résumé présent dans OpenAlex
- oui