Pan-genome analysis highlights the extent of genomic variation in cultivated and wild rice
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Résumé
The rich genetic diversity in Oryza sativa and Oryza rufipogon serves as the main sources in rice breeding. Large-scale resequencing has been undertaken to discover allelic variants in rice, but much of the information for genetic variation is often lost by direct mapping of short sequence reads onto the O. sativa japonica Nipponbare reference genome. Here we constructed a pan-genome dataset of the O. sativa–O. rufipogon species complex through deep sequencing and de novo assembly of 66 divergent accessions. Intergenomic comparisons identified 23 million sequence variants in the rice genome. This catalog of sequence variations includes many known quantitative trait nucleotides and will be helpful in pinpointing new causal variants that underlie complex traits. In particular, we systemically investigated the whole set of coding genes using this pan-genome data, which revealed extensive presence and absence of variation among rice accessions. This pan-genome resource will further promote evolutionary and functional studies in rice. A pan-genome dataset of the Oryza sativa–Oryza rufipogon species complex generated through deep sequencing and de novo genome assembly of 66 divergent accessions will be helpful in pinpointing new causal variants underlying complex traits and in promoting evolutionary and functional studies in rice.
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La notice
- Revue
- Nature Genetics
- Thématique
- Genetic Mapping and Diversity in Plants and Animals
- Domaine
- Biochemistry, Genetics and Molecular Biology
- Établissements canadiens
- —
- Organismes subventionnaires
- Institute of GeneticsNational Natural Science Foundation of ChinaChinese Academy of SciencesMinistry of Education, Culture, Sports, Science and Technology
- Mots-clés
- BiologyOryza rufipogonOryza sativaGenomeGeneticsStructural variationWhole genome sequencingJaponicaGenetic variationGenomicsQuantitative trait locusOryzaReference genomeGenetic diversityGenePopulationBotany
- Résumé présent dans OpenAlex
- oui