RETRACTED ARTICLE: The effect of zinc and vitamin E cosupplementation on metabolic status and its related gene expression in patients with gestational diabetes
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Dossier post-publication
- Nature
- Retraction
- Motif
- Concerns/Issues about Data;Concerns/Issues about Results and/or Conclusions;Investigation by Journal/Publisher;Investigation by Third Party;Objections by Author(s);Unreliable Results and/or Conclusions;Upgrade/Update of Prior Notice(s);
- Date
- 6/18/2024 0:00
- Signalé par OpenAlex ?
- Oui
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Résumé
Objective: The aim of this study was to determine the effects of zinc and vitamin E cosupplementation on metabolic status and gene expression related to insulin and lipid metabolism in women with gestational diabetes mellitus (GDM).Methods: Fifty-four women, in the age range of 18–40 years, diagnosed with GDM were recruited for this randomized, double-blinded, placebo-controlled trial. Subjects were randomly allocated into two intervention groups to either taking 233 mg/day Zinc Gluconate plus 400-IU/day vitamin E supplements or placebo (n = 27 each group) for 6 weeks. Gene expression related to insulin and lipid metabolism was evaluated in peripheral blood mononuclear cells (PBMCs) of women with GDM using RT-PCR method.Results: Participants who received zinc plus vitamin E supplements had significantly lower serum insulin levels (β = −3.81; 95% CI, −5.90, −1.72; p = .001), homeostasis model of assessment-insulin resistance (β = −0.96; 95% CI, −1.54, −0.38; p = .002), serum total-cholesterol (β = −8.56; 95% CI, −16.69, −0.43; p = .03) and low density lipoprotein-cholesterol (LDL)-cholesterol (β = −8.72; 95% CI, −15.27, −2.16; p = .01), and higher quantitative insulin sensitivity check index (β = 0.01; 95% CI, 0.005, 0.02; p = .007) compared with the placebo. Moreover, zinc and vitamin E cosupplementation upregulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-γ; p = .03) and low-density lipoprotein receptor (LDLR; p = .04) compared with the placebo. Though, zinc and vitamin E combination did not affect other metabolic parameters.Conclusions: Overall, zinc and vitamin E cosupplementation for 6 weeks in women with GDM significantly improved insulin metabolism, lipid profile, and the gene expression levels of PPAR-γ and LDLR.
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La notice
- Revue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Thématique
- Pregnancy and preeclampsia studies
- Domaine
- Medicine
- Établissements canadiens
- University of Calgary
- Organismes subventionnaires
- —
- Mots-clés
- Internal medicineEndocrinologyGestational diabetesMedicineInsulin resistanceInsulinPlaceboVitaminBlood lipidsHomeostatic model assessmentDiabetes mellitusCholesterolGestationBiologyPregnancy
- Résumé présent dans OpenAlex
- oui