Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults
Pourquoi ce travail est-il dans la base ?
Une base qui oublie comment elle a trouvé un travail ne peut pas être vérifiée. Voici les voies qui ont admis celui-ci.
Aucune affiliation canadienne. Une base fondée sur la seule affiliation (le devis habituel) n'aurait jamais vu ce travail. C'est l'un des travaux qui justifient l'inversion de la base.
Résumé
Importance: Increasing evidence shows that physical activity is associated with reduced risk for depression, pointing to a potential modifiable target for prevention. However, the causality and direction of this association are not clear; physical activity may protect against depression, and/or depression may result in decreased physical activity. Objective: To examine bidirectional relationships between physical activity and depression using a genetically informed method for assessing potential causal inference. Design, Setting, and Participants: This 2-sample mendelian randomization (MR) used independent top genetic variants associated with 2 physical activity phenotypes-self-reported (n = 377 234) and objective accelerometer-based (n = 91 084)-and with major depressive disorder (MDD) (n = 143 265) as genetic instruments from the largest available, nonoverlapping genome-wide association studies (GWAS). GWAS were previously conducted in diverse observational cohorts, including the UK Biobank (for physical activity) and participating studies in the Psychiatric Genomics Consortium (for MDD) among adults of European ancestry. Mendelian randomization estimates from each genetic instrument were combined using inverse variance weighted meta-analysis, with alternate methods (eg, weighted median, MR Egger, MR-Pleiotropy Residual Sum and Outlier [PRESSO]) and multiple sensitivity analyses to assess horizontal pleiotropy and remove outliers. Data were analyzed from May 10 through July 31, 2018. Main Outcomes and Measures: MDD and physical activity. Results: GWAS summary data were available for a combined sample size of 611 583 adult participants. Mendelian randomization evidence suggested a protective relationship between accelerometer-based activity and MDD (odds ratio [OR], 0.74 for MDD per 1-SD increase in mean acceleration; 95% CI, 0.59-0.92; P = .006). In contrast, there was no statistically significant relationship between MDD and accelerometer-based activity (β = -0.08 in mean acceleration per MDD vs control status; 95% CI, -0.47 to 0.32; P = .70). Furthermore, there was no significant relationship between self-reported activity and MDD (OR, 1.28 for MDD per 1-SD increase in metabolic-equivalent minutes of reported moderate-to-vigorous activity; 95% CI, 0.57-3.37; P = .48), or between MDD and self-reported activity (β = 0.02 per MDD in standardized metabolic-equivalent minutes of reported moderate-to-vigorous activity per MDD vs control status; 95% CI, -0.008 to 0.05; P = .15). Conclusions and Relevance: Using genetic instruments identified from large-scale GWAS, robust evidence supports a protective relationship between objectively assessed-but not self-reported-physical activity and the risk for MDD. Findings point to the importance of objective measurement of physical activity in epidemiologic studies of mental health and support the hypothesis that enhancing physical activity may be an effective prevention strategy for depression.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
La notice
- Revue
- JAMA Psychiatry
- Thématique
- Genetic Associations and Epidemiology
- Domaine
- Biochemistry, Genetics and Molecular Biology
- Établissements canadiens
- —
- Organismes subventionnaires
- Division of Cancer Epidemiology and Genetics, National Cancer InstituteJanssen Research and DevelopmentNational Institute of Mental HealthNHLBI Division of Intramural ResearchInstitute of Molecular and Cell BiologyInstitute of GeneticsDepartment of Psychiatry, University of TorontoDepartment of Psychiatry, Columbia UniversityBiotechnology and Biological Sciences Research CouncilStanley Center for Psychiatric Research, Broad InstituteUniversity of North Carolina at Chapel HillSchool of Medicine, Emory UniversityCentre for Cognitive Ageing and Cognitive EpidemiologyH. Lundbeck A/SMedical Research CouncilTartu ÜlikoolHáskóli ÍslandsMedizinische Fakultät der Albert-Ludwigs-Universität FreiburgRegion HovedstadenRheinische Friedrich-Wilhelms-Universität BonnUniversità degli Studi di TrentoNewcastle UniversityUniversitair Medisch Centrum GroningenLeids Universitair Medisch CentrumRigshospitaletAarhus UniversitetshospitalUniversidad de GranadaQueensland Brain InstituteUniversity of QueenslandKarolinska InstitutetStatens Serum InstitutGGZ inGeestRijksuniversiteit GroningenUniversity of GlasgowUniversiteit LeidenTrinity College DublinUniversity of TorontoVrije Universiteit AmsterdamUniversity of OxfordAarhus UniversitetMassachusetts Institute of TechnologyUniversität BaselQIMR Berghofer Medical Research InstituteNational Cancer InstituteLundbeckfondenUniversity College LondonAlbert-Ludwigs-Universität FreiburgKing's College LondonVirginia Commonwealth UniversityBroad InstituteF. Hoffmann-La RocheCardiff UniversityJames Cook UniversityUniversity of Southern CaliforniaWellcome TrustDalhousie UniversityUniversitätsmedizin GöttingenQueensland University of TechnologyBrigham and Women's HospitalKaiser PermanenteWestfälische Wilhelms-Universität MünsterEmory UniversityGentofte HospitalNational Institute for Health and Care ResearchMassachusetts General HospitalPfizerMcDonnell Center for Systems NeuroscienceUniversity of California, San DiegoJohns Hopkins UniversityAmgen
- Mots-clés
- Depression (economics)Physical activityPsychologyClinical psychologyMedicinePsychiatryPhysical medicine and rehabilitation
- Résumé présent dans OpenAlex
- oui