Sex‐specific associations of human milk long‐chain polyunsaturated fatty acids and infant allergic conditions
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Association of human milk fatty acids with infant allergy; a clinical epidemiology question.
The study examines infant allergic conditions and human milk fatty acids rather than research itself.
Epidemiology of human-milk fatty acids and infant allergy; clinical nutrition cohort study.
Résumé
BACKGROUND: Polyunsaturated fatty acids (PUFAs) may influence immune development. We examined the association of PUFAs in human milk with food sensitization and atopic dermatitis among breastfed infants. METHODS: In a selected subgroup of 1109 mother-infant dyads from the CHILD Cohort Study, human milk was analyzed by gas-liquid chromatography to quantify PUFAs including arachidonic acid (ARA) and docosahexaenoic acid (DHA). At 1 year of age, food sensitization was determined by skin-prick testing for egg, peanut, cow's milk, and soybean, and atopic dermatitis was diagnosed by pediatricians. Logistic regression analyses controlled for breastfeeding exclusivity, family history of atopy, and other potential confounders. RESULTS: Overall, 184 infants (17%) were sensitized to one or more food allergens and 160 (14%) had atopic dermatitis. Sex-specific associations were observed between these conditions and milk PUFAs. Girls receiving human milk with lower proportions of DHA had lower odds of food sensitization (aOR 0.35; 95% CI 0.12, 0.99 for lowest vs highest quintile), and a clear dose-dependent association was observed for the ARA/DHA ratio (aOR 2.98; 95% CI 1.10, 8.06 for lowest vs highest quintile). These associations were not seen in boys. Similar sex-specific tendencies were observed for atopic dermatitis. CONCLUSIONS: Human milk PUFA proportions and their ratios are associated with infant atopic conditions in a sex-specific manner. In female infants, a higher ratio of ARA/DHA may reduce the risk of food sensitization and atopic dermatitis. Further research is needed to determine the underlying mechanisms and clinical relevance of this sex-specific association.
Conservé avec la notice de tri, où il sert de preuve aux étiquettes ci-dessus.
La notice
- Revue
- Pediatric Allergy and Immunology
- Thématique
- Fatty Acid Research and Health
- Domaine
- Nursing
- Établissements canadiens
- University of AlbertaUniversity of British ColumbiaUniversity of TorontoMcMaster UniversityUniversity of ManitobaChildren's Hospital Research Institute of Manitoba
- Organismes subventionnaires
- Canadian Institutes of Health ResearchMitacsUniversity of TorontoAllerGenCanadian Institute for Advanced ResearchCanadian Lung AssociationUniversity of AlbertaChildren's Hospital FoundationMedelaMcMaster UniversityBill and Melinda Gates FoundationManitoba Medical Service FoundationResearch ManitobaCanada Research ChairsAstraZeneca
- Mots-clés
- MedicineAtopic dermatitisBreastfeedingPolyunsaturated fatty acidInfant formulaAtopyOdds ratioFood allergyDocosahexaenoic acidAllergySensitizationConfoundingPhysiologyImmunologyFatty acidInternal medicinePediatricsBiology
- Résumé présent dans OpenAlex
- oui