Faculty Opinions recommendation of Implantable cardioverter-defibrillators in tetralogy of Fallot.
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Faculty Opinions recommendation of a clinical cohort study of implantable defibrillators in tetralogy of Fallot; a commentary on a clinical finding, not a study of peer review.
This post-publication recommendation comments on a biomedical study without studying peer review itself.
Faculty Opinions post-publication rating of a clinical ICD paper; uses review format, does not study peer review.
Résumé
BACKGROUND: Tetralogy of Fallot is the most common form of congenital heart disease in implantable cardioverter-defibrillator (ICD) recipients, yet little is known about the value of ICDs in this patient population.METHODS AND RESULTS: We conducted a multicenter cohort study in high-risk patients with Tetralogy of Fallot to determine actuarial rates of ICD discharges, identify risk factors, and characterize ICD-related complications. A total of 121 patients (median age 33.3 years; 59.5% male) were enrolled from 11 sites and followed up for a median of 3.7 years. ICDs were implanted for primary prevention in 68 patients (56.2%) and for secondary prevention in 53 (43.8%), defined by clinical sustained ventricular tachyarrhythmia or resuscitated sudden death. Overall, 37 patients (30.6%) received at least 1 appropriate and effective ICD discharge, with a median ventricular tachyarrhythmia rate of 213 bpm. Annual actuarial rates of appropriate ICD shocks were 7.7% and 9.8% in primary and secondary prevention, respectively (P=0.11). A higher left ventricular end-diastolic pressure (hazard ratio 1.3 per mm Hg, P=0.004) and nonsustained ventricular tachycardia (hazard ratio 3.7, P=0.023) independently predicted appropriate ICD shocks in primary prevention. Inappropriate shocks occurred in 5.8% of patients yearly. Additionally, 36 patients (29.8%) experienced complications, of which 6 (5.0%) were acute, 25 (20.7%) were late lead-related, and 7 (5.8%) were late generator-related complications. Nine patients died during follow-up, which corresponds to an actuarial annual mortality rate of 2.2%, which did not differ between the primary and secondary prevention groups.CONCLUSIONS: Patients with tetralogy of Fallot and ICDs for primary and secondary prevention experience high rates of appropriate and effective shocks; however, inappropriate shocks and late lead-related complications are common. PMID: 18172030
Conservé avec la notice de tri, où il sert de preuve aux étiquettes ci-dessus.
La notice
- Revue
- Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Thématique
- Congenital Heart Disease Studies
- Domaine
- Medicine
- Établissements canadiens
- Toronto General HospitalUniversity Health Network
- Organismes subventionnaires
- —
- Mots-clés
- MedicineTetralogy of FallotVentricular tachycardiaCardiologyImplantable cardioverter-defibrillatorInternal medicineHazard ratioPopulationVentricular fibrillationHeart diseaseConfidence interval
- Résumé présent dans OpenAlex
- oui