A revisit of the interaction of gaseous ozone with aqueous iodide. \nEstimating the contributions of the surface and bulk reactions
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Résumé
Hydrogels are everyday materials characterized by their remarkable properties, of bridging the gap between liquid and solid states. While most hydrogels are traditionally formed from polymers, biomolecules can also undergo gelation, as seen with proteins (e.g., collagen), enabling numerous applications. Peptide-based low-molecular-weight hydrogels (LMWHs), composed of amino acids, have emerged as innovative materials with a broad range of biomedical and biotechnological applications, gaining commercial interest in the 2010s. However, natural peptides composed solely of proteinogenic amino acids present several drawbacks, requiring structural or chemical modifications to enhance their performance. Additionally, multicomponent approaches, which involve combining multiple compounds to form hydrogels, have recently gained prominence as a promising strategy for developing more versatile and efficient systems. In this context, we explore emerging hybrid molecules, i.e., peptides functionalized with DNA bases (i.e., adenine, thymine, guanine, and cytosine), known as nucleopeptides. These compounds have shown encouraging results, yet much remains to be explored to unlock their full potential. In this study, we present a novel series of six (nucleo)-peptides derived from two distinct peptide sequences, Phe-Glu-Phe-Glu and Phe-Lys-Phe-Lys, negatively and positively charged at physiological pH, respectively, making them complementary in terms of electrostatic interactions. These peptides are functionalized with one of the four DNA nucleobases, introduced via a peptide nucleic acid (PNA) moiety. Thus, through a comprehensive multiscale systematic study, we report herein on the impact of charge complementarity and/or nucleobase-pair complementarity on the mechanical and physicochemical properties of the resulting multicomponent hydrogels (including gelation time, sol-gel transition temperature, stiffness, resistance to external stress, fibrillar network morphology, etc.). Then, the results highlight the undeniable potential of this approach, demonstrating that careful selection of components allows the fine-tuning of hydrogel properties. Interestingly, our findings reveal unexpected behaviors, underscoring the complexity of these bioinspired hybrid multicomponent systems while reinforcing their potential for the development of high-performance and innovative supramolecular hydrogels.
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La notice
- Revue
- HAL (Le Centre pour la Communication Scientifique Directe)
- Thématique
- Conducting polymers and applications
- Domaine
- Materials Science
- Établissements canadiens
- —
- Organismes subventionnaires
- Agencia Estatal de InvestigaciónEuropean Regional Development FundNatural Sciences and Engineering Research Council of CanadaNational Institutes of HealthInstitut Pierre-Gilles de GennesInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'EnvironnementCentro Singular de Investigación de GaliciaLaboratoires d'excellence Nanostructures en Interaction avec leur EnvironnementInstitut Carnot Santé AnimaleUniversité de Recherche Paris Sciences et LettresUniversité de RouenUniversidad de Castilla-La ManchaRWTH Aachen UniversityUniversidad de ZaragozaUniverzita Karlova v PrazeLigue Contre le CancerCentre National de la Recherche ScientifiqueUniversité de BordeauxChina Scholarship CouncilPetroChina Company LimitedCHIST-ERAUniversité Catholique de LouvainMinistère de l'Enseignement Supérieur et de la RechercheAgence Nationale de la RechercheEquipexGobierno de AragónDeutsche ForschungsgemeinschaftMinisterio de Economía y CompetitividadNational Natural Science Foundation of ChinaInfrastructures en Biologie Santé et AgronomieCentre in Green Chemistry and CatalysisFonds De La Recherche Scientifique - FNRSGrantová Agentura České RepublikyMinisterio de Ciencia, Innovación y UniversidadesMinisterio de Ciencia e InnovaciónEuropean CommissionUniversité de StrasbourgIndian National Science AcademyXunta de GaliciaMinistère de l'Enseignement Supérieur et de la Recherche ScientifiqueLABoratoires d’EXcellence ARCANENational Science Foundation
- Mots-clés
- OligomerMorphology (biology)DopingMaterials scienceNanotechnologyPolymer scienceChemical engineeringPolymer chemistryEngineeringOptoelectronicsGeology
- Résumé présent dans OpenAlex
- oui