MétaCan
Menu
Back to cohort
Record W1535405040 · doi:10.1128/9781555815608.ch5

Pathogenicity of <i>Enterobacter sakazakii</i>

2014· book-chapter· en· W1535405040 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueASM Press eBooks · 2014
Typebook-chapter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEnterobacteriaceae and Cronobacter Research
Canadian institutionsHealth Canada
Fundersnot available
KeywordsMeningitisEnterobacterNecrotizing enterocolitisBacteremiaPathogenBiologyPathogenesisEnterocolitisMicrobiologyImmunologyMedicinePediatricsInternal medicineAntibioticsEscherichia coliGene

Abstract

fetched live from OpenAlex

Enterobacter sakazakii is an emerging food-borne pathogen that has increasingly raised interest among the scientific community, health care providers, and the food industry since the early 1980s, when it was accepted as a new species. This chapter attempts to summarize research endeavors aimed at understanding the pathogenesis of this important food-borne pathogen. The first two known cases of E. sakazakii meningitis date from 1958 and were first reported in 1961. Subsequently, cases of meningitis, septicemia, and necrotizing enterocolitis due to this organism have been reported worldwide. E. sakazakii adherence to the cell lines increased with a higher multiplicity of infection and was maximal at the late bacterial exponential growth phase. Once E. sakazakii makes its way past the gastrointestinal tract to the bloodstream, it is likely that it attaches to endothelial cells and then somehow crosses through the blood-brain barrier to infect the meninges and brain. Interestingly, using meningitis and bacteremia alone to characterize the disease, invasive infant cases were divided into two groups based on gestational age and birth weight. The interest in the causal relationship between powdered infant formula (PIF) and this emerging food-borne pathogen has led to an interest in ascertaining its mechanism(s) of pathogenicity.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.812
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.248
Teacher spread0.226 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it