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Record W1579957049 · doi:10.1002/9780471740360.ebs1323

Gene Expression Profiles, Nonlinear System Identification In

2006· other· en· W1579957049 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueWiley Encyclopedia of Biomedical Engineering · 2006
Typeother
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGene expression and cancer classification
Canadian institutionsQueen's University
Fundersnot available
KeywordsIdentification (biology)Computer scienceExpression (computer science)Focus (optics)Class (philosophy)Data miningNonlinear systemMachine learningMicroarray analysis techniquesComputational biologyArtificial intelligenceGeneGene expressionBiologyGenetics

Abstract

fetched live from OpenAlex

Abstract The recent advent of the microarray has enabled simultaneous monitoring of the expression of thousands of genes, and with it have come vexing questions of how best to interpret the new wealth of data being gathered. Although many important uses have been made of this technology, such as for diagnosis, prediction of treatment response and clinical outcome, and prediction of metastatic status, we will focus attention on only these specific applications. It is clear that there is no consensus at present on the most effective methods for analysis of such gene expression data, and here we consider only some approaches that have forged a link between nonlinear system identification and construction of effective gene‐expression‐based class predictors. As we will discuss, one hallmark of these approaches is that they can produce effective predictors with considerably less training data than some statistically based prediction methods.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.635
Threshold uncertainty score0.921

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.210
Teacher spread0.206 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it