Is there a higher risk of restless legs syndrome in peripheral neuropathy?
Why this work is in the frame
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Bibliographic record
Abstract
<b>Objective:</b> Associations between peripheral neuropathy and restless legs syndrome (RLS) have been described, but have not been consistently reproduced. If RLS prevalence is truly increased by neuropathy, this has important implications for RLS pathophysiology. <b>Methods:</b> In a case-control design, 245 patients with peripheral neuropathy and 245 age- and sex-matched controls were screened for RLS using a standardized phone questionnaire based on international RLS diagnostic criteria. All persons who answered yes to three of four criteria were considered screen-positive. All screen-positive patients underwent a confirmatory diagnostic evaluation by a movement disorders specialist blinded to the neuropathy status of the patient. RLS prevalence was calculated and compared using Fisher exact test. <b>Results:</b> A total of 65 (26.5%) patients with neuropathy screened positive compared to 25 (10.2%) controls (<i>p</i> < 0.0001). However, the diagnosis was confirmed in only 46% of screen-positive patients with neuropathy, vs 80% of controls (<i>p</i> = 0.005). Cramps and paresthesia without true diurnal variation or rest exacerbation were the commonest causes of false-positive screens. After diagnostic confirmation, the overall prevalence of RLS did not differ between neuropathy patients and controls (12.2% vs 8.2%, <i>p</i> = 0.14). However, when classified by etiology, RLS was found in 14/72 (19.4%) patients with hereditary neuropathy, a prevalence higher than found in controls (<i>p</i> = 0.016) and acquired neuropathy (9.2%, <i>p</i> = 0.033). Among patients with neuropathy, those with RLS more commonly had a family history of RLS (37% vs 15%, <i>p</i> = 0.007) and were younger (49.9 vs 61.4, <i>p</i> = 0.0003). <b>Conclusions:</b> Restless legs syndrome is more prevalent among patients with hereditary neuropathy, but not in those with acquired neuropathies. <b>CIDP</b> = chronic inflammatory demyelinating polyneuropathy; <b>GBS</b> = Guillain-Barré syndrome; <b>HMSN</b> = hereditary motor sensory neuropathy; <b>HSAN</b> = hereditary sensory and autonomic neuropathy; <b>IRLSSG</b> = International Restless Legs Study Group; <b>MGUS</b> = monoclonal gammopathy of uncertain significance; <b>NCS</b> = nerve conduction studies; <b>PPV</b> = positive predictive value; <b>RLS</b> = restless legs syndrome.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it