MétaCan
Menu
Back to cohort
Record W1975117991 · doi:10.1300/j133v03n01_06

Pyrrolizidine Alkaloids in Higher Plants

2001· article· en· W1975117991 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueJournal of Nutraceuticals Functional & Medical Foods · 2001
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPlant Toxicity and Pharmacological Properties
Canadian institutionsWestern University
Fundersnot available
KeywordsPyrrolizidineSenecioPyrrolizidine alkaloidPhytochemicalTraditional medicineBiologyCrotalariaMedicinal plantsToxicityToxicologyBotanyMedicine

Abstract

fetched live from OpenAlex

ABSTRACT Pyrrolizidine alkaloids (PAs) are a class of phytochemi-cals found in more than 350 plant species, with the main suspect species being Heliotroprium, Senecio, Crotalaria, and Symphytum. Many of these types of alkaloids have been shown to have important pharmacological properties, but many others have demonstrated severe toxicity. Consumption of plants containing these alkaloids has been associated with potentially fatal hepatic veno-occlusive disease (Budd-Chiari Syndrome), carcinogenesis, and fibrotic lung disease. This article reviews literature published on comfrey (Symphytum officinale), as a case-study of a potentially toxic plant commonly consumed in North America as an herbal remedy. The pharmacology of the plant is discussed together with the phytochemical features lending the plant to toxicity problems. Finally, there is an attempt to estimate the human intake of potentially toxic pyrrolizidine alkaloids in high-risk areas, and a discussion of reported case-studies of PA poisoning.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.800
Threshold uncertainty score0.998

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.082
GPT teacher head0.321
Teacher spread0.240 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it