Oxidative damage, ageing, and life-history evolution: where now?
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.253 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
The idea that resources are limited and animals can maximise fitness by trading costly activities off against one another forms the basis of life-history theory. Although investment in reproduction or growth negatively affects survival, the mechanisms underlying such trade-offs remain obscure. One plausible mechanism is oxidative damage to proteins, lipids, and nucleic acids caused by reactive oxygen species (ROS). Here, we critically evaluate the premise that ROS-induced oxidative damage shapes life history, focussing on birds and mammals, and highlight the importance of ecological studies examining free-living animals within this experimental framework. We conclude by emphasising the value of using multiple assays to determine oxidative protection and damage. We also highlight the importance of using standardised and appropriate protocols, and discuss future research directions.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Trends in Ecology & Evolution
- Topic
- Genetics, Aging, and Longevity in Model Organisms
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- Institute of GeneticsInstitute of Genetics and Developmental Biology, Chinese Academy of SciencesBiotechnology and Biological Sciences Research CouncilDirectorate for Biological SciencesChinese Academy of SciencesNatural Environment Research CouncilSight Research UK
- Keywords
- Oxidative damageAgeingOxidative phosphorylationBiologyMechanism (biology)Nucleic acidFree-radical theory of agingLife historyLife history theoryEvolutionary biologyReactive oxygen speciesZoologyOxidative stressEcologyCell biologyBiochemistryGenetics
- Has abstract in OpenAlex
- yes