Revealing a Role of MicroRNAs in the Regulation of the Biological Clock
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
In the last decade numerous studies have unveiled the pervasive role of microRNAs (miRNAs), a class of small, non-coding transcripts, in post-transcriptional gene regulation in biological processes ranging from development to cancer. Until recently, the circadian clock has been modeled as simple, interlocking, transcriptional feedback loops that drive rhythmic gene expression of a few core 'clock' determinants. The biological implications of miRNAs are extended further by our recent discovery that miRNAs are expressed in the suprachiasmatic nuclei (SCN), the master circadian clock in mammals, in a rhythmic and inducible fashion, and modulate the intrinsic pacemaker activity and resetting capacity of the SCN. In this review, we will discuss the specific roles of miRNA-(miR-)132 and miR-219 in the SCN, as well as a more general outlook on this newly elucidated layer of circadian clock regulation: inducible translation control via miRNAs.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it