Scaling the Microrheology of Living Cells
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Abstract
We report a scaling law that governs both the elastic and frictional properties of a wide variety of living cell types, over a wide range of time scales and under a variety of biological interventions. This scaling identifies these cells as soft glassy materials existing close to a glass transition, and implies that cytoskeletal proteins may regulate cell mechanical properties mainly by modulating the effective noise temperature of the matrix. The practical implications are that the effective noise temperature is an easily quantified measure of the ability of the cytoskeleton to deform, flow, and reorganize.
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The record
- Venue
- Physical Review Letters
- Topic
- Cellular Mechanics and Interactions
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- Dalhousie University
- Funders
- National Heart, Lung, and Blood InstituteNational Institutes of Health
- Keywords
- MicrorheologyScalingCytoskeletonMeasure (data warehouse)Variety (cybernetics)Matrix (chemical analysis)Noise (video)Statistical physicsPhysicsMaterials scienceNanotechnologyBiological systemComputer scienceCellRheologyChemistryBiologyThermodynamics
- Has abstract in OpenAlex
- yes