Sustained Clinical Response as an Endpoint in Treatment Trials of Clostridium difficile-Associated Diarrhea
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- Meta-epidemiology (narrow)
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: Bench or experimentalConsensus signal: Bench or experimental
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.273
- Threshold uncertainty score
- 1.000
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.325 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Recurrence of diarrhea following initially successful treatmentis a major shortcoming in the treatment of Clostridium diffi-cile-associated diarrhea (CDAD). Sustained response is a clinical endpoint proposed to account for differences among treatment agents with respect to a combination of initial response/cure and recurrence. Until recently, vancomycin was the only FDA-approved treat-ment for C. difficile infection (CDI). Treatment guidelines have recommended metronidazole for a first occurrence of nonsevere CDI and for a first relapse or reinfection (2, 3, 4). Vancomycin and metronidazole are both effective in providing initial response, with85 % cure rates, but 20 to 40 % of patients whose symptoms resolve have recurrent disease caused by relapse of the original infection or reinfection from external sources (2, 3, 4). In parallel with changes in strain prevalence and severity of disease, clinical response rates have changed with metronidazole during the last
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Antimicrobial Agents and Chemotherapy
- Topic
- Clostridium difficile and Clostridium perfringens research
- Field
- Medicine
- Canadian institutions
- University of Calgary
- Funders
- U.S. Food and Drug AdministrationU.S. Department of Veterans Affairs
- Keywords
- Clostridium difficileDiarrheaMedicineClinical endpointClinical trialClostridiumClostridium InfectionsMicrobiologyClostridiaceaeEndpoint DeterminationInternal medicineAntibioticsIntensive care medicineBiologyBacteria
- Has abstract in OpenAlex
- yes