Heritability of P300 amplitude development from adolescence to adulthood
Bibliographic record
Abstract
Early adulthood is a period of late brain development corresponding to the age of onset for psychopathology associated with P300 amplitude reductions. Although amplitude from a single occasion is heritable, little is known about genetic influences on change during this period. This is the first study of P300 change to combine latent growth and twin models. P300 at Pz was measured up to three times at approximately ages 17, 20, and 23 in monozygotic and dizygotic male twins using a visual task. P300 decreased with age. Correlations indexing the stability of amplitude over time were high (median r=.72) and almost 90% of the stable variance (i.e., the model intercept) was attributable to genetic influences. The rate of decrease was heritable, and the genes influencing intercept may be the same ones influencing change. Finally, intercept was more heritable than amplitude at any single time point. Intercept may be a more useful aid in the search for genes associated with relevant psychopathology than single measures of P300. Over a broader age range growth indices may be useful "developmental" endophenotypes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".