Influence of Nocturnal Oxygen Desaturation on Circadian Rhythm of Testosterone Secretion
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Bibliographic record
Abstract
To investigate the influence of nocturnal oxygen desaturation on the circadian rhythm of testosterone secretion, polysomnography was performed on 2 consecutive nights in 24 male subjects who complained of loud snoring and/or obesity. During the first night, we collected blood samples every 4 h via a catheter and measured serum testosterone. We arbitrarily defined severe oxygen desaturation as that exceeding the baseline SaO2 by 4% during 80 min of total sleep time. The subjects were divided into 2 groups from the data of the second night; one was the severe desaturation group as mentioned above, and those who suffered less desaturation were classified as the free to mild oxygen desaturation group. We found that in the latter group peak testosterone levels appeared at 6 a.m. On the other hand, the severe desaturation group exhibited delayed peak testosterone levels, i.e. at 10 a.m. We calculated the ratio of the testosterone level at 10 a.m. to that at 6 a.m., and found a significant correlation between this ratio and total desaturation time (r = 0.446, p less than 0.05). These data suggest that severe oxygen desaturation may alter the circadian rhythm of testosterone secretion.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it