A comparative analysis of the effect of antibiotic treatment and enteric infection on intestinal homeostasis
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The intestinal metabolome is a rich collection of molecules with specialized functions and important physiological effects. Many insults such as enteric infection and microbiota disruption by antibiotics can have profound effects in the metabolic homeostasis of the gut. We have recently shown that Salmonella infection and antibiotic treatment of mice drastically alter the intestinal metabolome. Particularly, host hormone metabolism was significantly altered by both insults. Infection resulted in a net increase in the production of both steroids and eicosanoids, whereas antibiotic treatment seemed to reduce the production of these hormones. Our results suggest that both intestinal pathogens and commensals affect common metabolic functions and that this phenomenon may have implications for the interactions between microbes and their hosts.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it