Abstract 239: Capsaicin may reduce the metastatic burden in the transgenic adenocarcioma of the mouse prostate (TRAMP) model
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Bibliographic record
Abstract
Abstract Introduction and Objective: A large body of evidence supports the role of dietary factors in prostate cancer development and progression. We are interested in investigating the chemopreventive potential of capsaicin, the active compound in chilli peppers that is traditionally used topically to treat various pain-related syndromes. Recently capsaicin has been demonstrated to have anti-carcinogenic properties in vitro through a number of different mechanisms. In our study we aim to study the chemopreventive properties of capsaicin using the transgenic adenocarcinoma of the mouse prostate (TRAMP) model, a murine model that closely resembles the progression of human disease. Methodology: Thirty-five six-week old TRAMP x C57Bk mice were randomized into two groups: control or capsaicin. Mice received either capsaicin (5 mg/kg body weight) or vehicle (saline) three times a week by oral gavage until the age of 30 weeks. Body weight was measured thrice weekly. All mice were sacrificed at 30 weeks. Body weight, genito-urinary (GU) weight, tumour burden were assessed. Prostate, seminal vesicles, lung, liver, esophagus, lymph nodes and pancreas were obtained for histological analysis. Serum was collected at the termination of the study for analysis of serum capsaicin concentration. Prostate tumours were analyzed by immunohistochemical analysis using proliferative and mechanistic markers. All tumours were scored by an on-site pathologist according to the histopathic grading scale described by Hurwitz AA, et al. Results: Interim results revealed that higher percentage of high-grade cancer in control group (n = 18). The presence of PIN-like pre-cancerous lesions in only the treatment group and not the control group (n = 18). The capsaicin treated mice also demonstrated a reduced proportion of metastatic cancers compared to the control group. There were no significant changes in the GU wet weight between groups (n = 35). Immunohistochemical analysis of the prostate tumour is ongoing. Capsaicin was well tolerated, as there was no pathological liver or esophagus or gastrointestinal toxicities or difference in body weight between groups. Further results are currently under investigation. Conclusion: Interim results suggest that oral administration of capsaicin is well tolerated and may reduce the metastatic burden in the TRAMP model. Ongoing studies are currently underway to delineate the mechanism of action. Citation Format: Natalie A. Venier, Toshihiro Yamamoto, Linda Sugar, Neil Fleshner, Laurence Klotz, Vasundara Venkateswaran. Capsaicin may reduce the metastatic burden in the transgenic adenocarcioma of the mouse prostate (TRAMP) model. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 239. doi:10.1158/1538-7445.AM2014-239
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it