Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis
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No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
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- Teacher spread
- 0.228 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
<b>Objective: </b> Optical coherence tomography (OCT) noninvasively quantifies retinal nerve fiber layer (RNFL) thickness. Studies show RNFL thinning in multiple sclerosis (MS), and we assessed its association with brain atrophy. <b>Methods: </b> RNFL thickness was measured in 40 patients with MS and 15 controls. Brain parenchymal fraction (BPF) and partial brain volumes were estimated from cranial MRI scans using SIENA-X. Multiple linear regression modeling assessed the association between OCT and MRI measures of atrophy. <b>Results: </b> Minimum RNFL thickness and subject age together predict 21% (<i>p</i> = 0.005) of the variance in BPF in all patients with MS and 43% (<i>p</i> = 0.003) of the variance in BPF in the subgroup with relapsing remitting MS (RRMS; <i>n</i> = 20). The partial correlation coefficient between BPF and minimum RNFL thickness, controlling for age, is 0.46 (<i>p</i> = 0.003) in all patients with MS and 0.69 (<i>p</i> = 0.001) in patients with RRMS. These associations are driven by CSF volume but not by gray or white matter volume. There is no significant association of these variables among controls. <b>Conclusions: </b> In multiple sclerosis (MS), retinal nerve fiber layer thickness is associated with brain parenchymal fraction and CSF volume. These data suggest that quantification of axonal thickness in the retina by optical coherence tomography (OCT) provides concurrent information about MRI brain abnormality in MS. OCT should be examined in longitudinal studies to determine if it could be used as an outcome measure in clinical trials of neuroprotective drugs. <b>GLOSSARY: </b><b>BPF</b> = brain parenchymal fraction; <b>EDSS</b> = Expanded Disability Status Scale; <b>KKI</b> = Kennedy Krieger Institute; <b>MNI</b> = Montreal Neurological Institute; <b>MPRAGE</b> = magnetization-prepared rapid gradient echo; <b>MS</b> = multiple sclerosis; <b>OCT</b> = optical coherence tomography; <b>PPMS</b> = primary progressive MS; <b>RNFL</b> = retinal nerve fiber layer; <b>RRMS</b> = relapsing remitting MS; <b>SPMS</b> = secondary progressive MS; <b>TMV</b> = total macular volume.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Neurology
- Topic
- Multiple Sclerosis Research Studies
- Field
- Medicine
- Canadian institutions
- —
- Funders
- Johns Hopkins University
- Keywords
- Nerve fiber layerMultiple sclerosisAtrophyRetinalMedicineOptical coherence tomographyOphthalmologyWhite matterPathologyRetinaClinically isolated syndromeMagnetic resonance imagingBrain sizeRadiologyNeurosciencePsychology
- Has abstract in OpenAlex
- yes