Ventricular fibrillation, an uncontrolled arrhythmia seeking new targets
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract Ventricular antiarrhythmic drugs in current clinical use leave much to be desired in terms of safety and efficacy. With the exception of beta‐adrenoreceptor blockers, none of the available antiarrhythmic drugs have significantly improved survival after myocardial infarction. Amiodarone has shown marginal benefit but has several safety limitations. As a result, there is a large unmet medical need for a safe and effective drug to treat lethal ventricular arrhythmias. Despite the difficulties in developing such a drug, there are a few research programs dedicated to solving this unmet medical need. These include drugs that are targeted to the pathological substrate responsible for initiating arrhythmias and drugs that block multiple ion channels in a manner similar to amiodarone. A few research programs are directed toward other molecular targets. This article briefly reviews the active research programs in the pharmaceutical industry currently that are pursuing ventricular antiarrhythmic drugs. Drug Dev. Res. 55:45–52, 2002. © 2002 Wiley‐Liss, Inc.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it