Four faces of cellular senescence
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- Teacher spread
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Abstract
Cellular senescence is an important mechanism for preventing the proliferation of potential cancer cells. Recently, however, it has become apparent that this process entails more than a simple cessation of cell growth. In addition to suppressing tumorigenesis, cellular senescence might also promote tissue repair and fuel inflammation associated with aging and cancer progression. Thus, cellular senescence might participate in four complex biological processes (tumor suppression, tumor promotion, aging, and tissue repair), some of which have apparently opposing effects. The challenge now is to understand the senescence response well enough to harness its benefits while suppressing its drawbacks.
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The record
- Venue
- The Journal of Cell Biology
- Topic
- Telomeres, Telomerase, and Senescence
- Field
- Medicine
- Canadian institutions
- Université de MontréalCentre Hospitalier de l’Université de Montréal
- Funders
- Institute of Cancer ResearchNational Cancer InstituteNational Institutes of HealthInstitut Du Cancer de MontréalCancer Research SocietyU.S. Department of Energy
- Keywords
- SenescenceBiologyCarcinogenesisCellular senescenceCell biologyInflammationTumor promotionCancerMechanism (biology)Cell growthCancer researchImmunologyGeneticsPhenotype
- Has abstract in OpenAlex
- yes