MétaCan
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Cellular and molecular mechanisms of thoracic aortic aneurysms

2009· review· en· 332 citations· W2080113459 on OpenAlex· 10.1038/nrcardio.2009.191

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Bench or experimentalNot applicable
Classifier consensus
N/A
Teacher imitation scores

Codex

Other design0.673
Bench or experimental0.066
Not applicable0.045
Theoretical or conceptual0.005
Metaresearch0.005
Meta-epidemiology (broad)0.001
Bibliometrics0.001
Case report0.000
Systematic review0.000
Open science0.000
Scholarly communication0.000
Meta-analysis0.000
Research integrity0.000
Meta-epidemiology (narrow)0.000
Observational0.000
Science and technology studies0.000
Simulation or modelling0.000
Randomized trial0.000
Non-randomized trial0.000
Qualitative0.000

Gemma

Not applicable0.819
Bench or experimental0.371
Systematic review0.002
Theoretical or conceptual0.001
Bibliometrics0.001
Case report0.000
Metaresearch0.000
Open science0.000
Research integrity0.000
Meta-analysis0.000
Non-randomized trial0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000
Science and technology studies0.000
Scholarly communication0.000
Observational0.000
Randomized trial0.000
Qualitative0.000
Simulation or modelling0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.024
GPT teacher head0.377
Teacher spread
0.354 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Thoracic aortic aneurysms (TAA) increase the risk of aortic dissection or rupture and represent an important source of morbidity and mortality. Inherited forms of the disease, including Marfan syndrome, have been recognized for a long time but were considered degenerative diseases characterized by cystic medial necrosis of the aortic wall. Improved definition of the structure and function of the normal aortic wall, coupled with the discovery of genetic mutations in key regulatory molecules, have contributed to a more detailed understanding of the pathophysiology of syndromic, familial and sporadic TAAs. We here review the cellular and molecular mechanisms involved in TAA formation and outline areas for future research.

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