Pathogenesis of Human Coronaviruses Other than Severe Acute Respiratory Syndrome Coronavirus
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Human coronaviruses (HCoVs) are endemic, and infections mainly occur in the winter and early spring. The most probable route of entry of HCoV appears to be the nasal mucosa, and horizontal transmission via small aerosols is possible, at least for HCoV-229E. Although HCoVs other than SARS-CoV are primarily associated with mild upper and lower respiratory tract disease, with the common cold the typical HCoV-induced pathology, HCoV was regularly associated with severe respiratory distress in newborns and recognized as an important trigger of acute asthma exacerbations. More recently, both previously (229E and OC43) and newly (NL63 and HKU1) described HCoVs have been associated with more severe acute lower respiratory tract infection, including pneumonia, in both infants and immunocompromised patients. Moreover, various reports have implicated the 229E and OC43 groups in other pathologies, such as myocardites and meningitis and severe diarrhea. Over the years, several reports have also suggested a possible link between the presence of HCoV within the human central nervous system (CNS) and various neurological disorders such as multiple sclerosis (MS), Parkinson's disease (PD), and encephalitis. As for virus infections in general, the development of vaccines against HCoVs is the best way to prevent infection and disease. This chapter deals with recent advances in research and development on inhibitors that act at various steps of the virus replication cycle, from receptor binding to release of progeny infectious particles.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it