Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
fundA Canadian funder is recorded on the work.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.
VenueNeurology · 2015
Typereview
Languageen
FieldMedicine
TopicMigraine and Headache Studies
Canadian institutionsnot available
FundersFP7 HealthOffice of Research on Women's HealthNational Center for Research ResourcesNational Institute of Neurological Disorders and StrokeNational Cancer InstituteNational Institute on Drug AbuseGGZ inGeestNational Institute on AgingNational Institute on Alcohol Abuse and AlcoholismMassachusetts General HospitalScottish Funding CouncilNIHR Cambridge Biomedical Research CentreYale UniversityUniversity of Texas Health Science Center at HoustonTurun YliopistoUniversitätsklinikum Hamburg-EppendorfNational Institute of Allergy and Infectious DiseasesAustralian Research CouncilEuropean Social FundMedical Research CouncilUniversiteit LeidenNational Heart, Lung, and Blood InstituteStanley Center for Psychiatric Research, Broad InstituteUniversitätsklinikum TübingenNational Institutes of HealthHeinz Nixdorf StiftungNIHR Oxford Biomedical Research CentreVincent Fairfax Family FoundationCentre for Medical Systems BiologyUniversität UlmPaavo Nurmen SäätiöTampereen TuberkuloosisäätiöUniversité de BordeauxNational Institute of Child Health and Human DevelopmentEmil Aaltosen SäätiöLudwig-Maximilians-Universität MünchenOffice of Research and DevelopmentUniversitair Medisch Centrum GroningenNational Institute for Health and Care ResearchCenters for Disease Control and PreventionLeids Universitair Medisch CentrumNederlandse Organisatie voor Wetenschappelijk OnderzoekTampereen YliopistoJuho Vainion SäätiöZonMwU.S. Public Health ServiceStiftung zur Erforschung der Vaskulären DemenzTrimbos-instituutGGZ DrentheGGZ FrieslandDeutsche ForschungsgemeinschaftMünchner Zentrum für GesundheitswissenschaftenUniversity of WashingtonRivierduinenInstitut National de la Santé et de la Recherche MédicaleSamfundet FolkhälsanMinistero della SaluteBritish Heart FoundationNational Center for Advancing Translational SciencesEuropean Science FoundationBundesministerium für Bildung und ForschungTerveyden ja hyvinvoinnin laitosImperial College LondonKing's College LondonAcademy of FinlandNational Institute of Mental HealthHelse Sør-Øst RHFHunter Medical Research InstituteUniversity of BristolKelaErasmus Medisch CentrumVrije Universiteit AmsterdamUniversity of OxfordNational Health and Medical Research CouncilTurun Yliopistollinen KeskussairaalaAmerican Heart AssociationSuomen KulttuurirahastoUK-India Education and Research InitiativeStroke AssociationUniversitetet i OsloWellcome TrustJohns Hopkins UniversityNational Eye InstituteHelsingin YliopistoFolkhälsanin TutkimussäätiöInstitute of GeneticsBroad InstituteQIMR Berghofer Medical Research InstituteNational Human Genome Research InstituteNational Institute of Diabetes and Digestive and Kidney DiseasesHelsingin ja Uudenmaan SairaanhoitopiiriCambridge Institute for Medical Research, University of CambridgeChronic Disease Research FoundationNorges Teknisk-Naturvitenskapelige UniversitetBiomedicum Helsinki-säätiöHartstichtingCedars-Sinai Medical CenterEuropean CommissionSchool of Medicine, Boston UniversityNederlands Instituut voor Onderzoek van de GezondheidszorgU.S. Department of Veterans AffairsAmgenNIH Clinical CenterJuvenile Diabetes Research Foundation International
KeywordsMigraineAuraMigraine with auraStroke (engine)Familial hemiplegic migraineGenome-wide association studyIschemic strokeGenetic variationMedicineGenetic correlationGeneticsBiologyBioinformaticsInternal medicineSingle-nucleotide polymorphismGeneIschemiaGenotype
Abstract
fetched live from OpenAlexOBJECTIVE: To quantify genetic overlap between migraine and ischemic stroke (IS) with respect to common genetic variation. METHODS: We applied 4 different approaches to large-scale meta-analyses of genome-wide data on migraine (23,285 cases and 95,425 controls) and IS (12,389 cases and 62,004 controls). First, we queried known genome-wide significant loci for both disorders, looking for potential overlap of signals. We then analyzed the overall shared genetic load using polygenic scores and estimated the genetic correlation between disease subtypes using data derived from these models. We further interrogated genomic regions of shared risk using analysis of covariance patterns between the 2 phenotypes using cross-phenotype spatial mapping. RESULTS: We found substantial genetic overlap between migraine and IS using all 4 approaches. Migraine without aura (MO) showed much stronger overlap with IS and its subtypes than migraine with aura (MA). The strongest overlap existed between MO and large artery stroke (LAS; p = 6.4 × 10(-28) for the LAS polygenic score in MO) and between MO and cardioembolic stroke (CE; p = 2.7 × 10(-20) for the CE score in MO). CONCLUSIONS: Our findings indicate shared genetic susceptibility to migraine and IS, with a particularly strong overlap between MO and both LAS and CE pointing towards shared mechanisms. Our observations on MA are consistent with a limited role of common genetic variants in this subtype.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.439
Threshold uncertainty score0.977
Codex and Gemma teacher scores by category
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Teacher spread0.274 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
