Exposure to cues associated with palatable food reward results in a dopamine D2 receptor-dependent suppression of evoked synaptic responses in the entorhinal cortex
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Bibliographic record
Abstract
BACKGROUND: The lateral entorhinal cortex receives inputs from ventral tegmental area dopamine neurons that are activated by exposure to food-related cues, and exogenously applied dopamine is known to modulate excitatory synaptic responses within the entorhinal cortex. METHODS: The present study used in vivo synaptic field potential recording techniques to determine how exposure to cues associated with food reward modulates synaptic responses in the entorhinal cortex of the awake rat. Chronically implanted electrodes were used to monitor synaptic potentials in the entorhinal cortex evoked by stimulation of the piriform (olfactory) cortex, and to determine how synaptic responses are modulated by food-related cues. RESULTS: The amplitudes of evoked synaptic responses were reduced during exposure to cues associated with delivery of chocolate, and during delivery of chocolate for consumption at unpredictable intervals. Reductions in synaptic responses were not well predicted by changes in behavioural mobility, and were not fully blocked by systemic injection of either the D₁-like receptor antagonist SCH23390, or the muscarinic receptor antagonist scopolamine. However, the reduction in synaptic responses was blocked by injection of the D₂-like receptor antagonist eticlopride. CONCLUSIONS: Exposure to cues associated with palatable food results in a suppression of synaptic responses in olfactory inputs to the entorhinal cortex that is mediated in part by activation of dopamine D₂ receptors.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it