Resonant Formation of DNA Strand Breaks by Low-Energy (3 to 20 eV) Electrons
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Abstract
Most of the energy deposited in cells by ionizing radiation is channeled into the production of abundant free secondary electrons with ballistic energies between 1 and 20 electron volts. Here it is shown that reactions of such electrons, even at energies well below ionization thresholds, induce substantial yields of single- and double-strand breaks in DNA, which are caused by rapid decays of transient molecular resonances localized on the DNA's basic components. This finding presents a fundamental challenge to the traditional notion that genotoxic damage by secondary electrons can only occur at energies above the onset of ionization, or upon solvation when they become a slowly reacting chemical species.
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The record
- Venue
- Science
- Topic
- Radiation Effects and Dosimetry
- Field
- Agricultural and Biological Sciences
- Canadian institutions
- Medical Council of Canada
- Funders
- —
- Keywords
- ElectronIonizationAtomic physicsIonizing radiationSecondary electronsDNALow energyPhysicsChemistryIrradiationIonNuclear physics
- Has abstract in OpenAlex
- yes