Lactoferrin: influences on Langerhans cells, epidermal cytokines, and cutaneous inflammation
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
The three-model screen
all 1,000 screened works →All three models called this out of scope.
Lactoferrin effects on Langerhans cells and cutaneous inflammation; immunology.
This biomedical experiment studies lactoferrin and inflammation rather than research methodology.
Biomedical study of lactoferrin effects on Langerhans cells and cutaneous inflammation.
Abstract
It has been suggested previously that, in addition to other biological roles, lactoferrin (LF) may display antiinflammatory properties secondary to the regulation of cytokine expression. To explore this concept further, we have here examined in human volunteers the influence of recombinant homologous LF on the migration of epidermal Langerhans cells (LC), a process that is known to be dependent upon the local availability of certain proinflammatory cytokines including tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta). In common with previous studies in mice, it was found that topical administration of LF prior to exposure at the same site to the contact sensitizer diphenylcyclopropenone resulted in a significant reduction of allergen-induced LC migration from the epidermis (measured as a function of the frequency of CD1a+ or HLA-DR+ LC found in epidermal sheets prepared from punch biopsies of the treated skin sites). However, under the same conditions of exposure, LF was unable to influence migration of LC induced by the intradermal administration of TNF-alpha data consistent with the hypothesis that one action of LF in the skin is to regulate the local production of this cytokine. Further support for this hypothesis was derived from experiments conducted with IL-1beta. This cytokine is also able to induce the mobilization of LC following intradermal injection, although in this case, migration is known to be dependent upon the de novo production of TNF-alpha. We observed that prior exposure to LF resulted in a substantial inhibition of IL-1beta-induced LC migration, data again consistent with the regulation of TNF-alpha production by LF. Collectively, these results support the view that LF is able to influence cutaneous immune and inflammatory processes secondary to regulation of the production of TNF-alpha and possibly other cytokines.
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- Biochemistry and Cell Biology
- Topic
- Infant Nutrition and Health
- Field
- Nursing
- Canadian institutions
- —
- Funders
- —
- Keywords
- Proinflammatory cytokineCytokineLactoferrinEpidermis (zoology)ImmunologyTumor necrosis factor alphaLangerhans cellInflammationHuman skinIntradermal injectionInterleukinChemistryBiologyImmune systemBiochemistry
- Has abstract in OpenAlex
- yes