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Avian Influenza: An Ecological and Evolutionary Perspective for Waterbird Scientists

2006· article· en· W2113592059 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueWaterbirds · 2006
Typearticle
Languageen
FieldMedicine
TopicInfluenza Virus Research Studies
Canadian institutionsSimon Fraser UniversityMemorial University of Newfoundland
FundersNatural Sciences and Engineering Research Council of CanadaSimon Fraser UniversityWaterbird Society
KeywordsReassortmentInfluenza A virus subtype H5N1BiologyHighly pathogenicHost (biology)EcologyGenomeEvolutionary biologyBird migrationEvolutionary ecologyLineage (genetic)ZoologyVirusVirologyGeneGeneticsCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)Disease

Abstract

fetched live from OpenAlex

Highly pathogenic avian influenza (HPAI) type A of the subtype H5N1 has recently spread widely and rapidly across Eurasia, and even to Africa, with deaths of both wild and domestic birds recorded. There are fears that it may soon spread to the Americas. Media accounts, communications from international bodies and national governments, and even some of the professional research literature attributes the spread, in part, to movements of HP strains by migratory birds. The origin of highly pathogenic strains is attributed to mutations, or to reassortment of virus genes from different host species. In this paper we review these hypotheses in light of knowledge about the ecology and evolution of avian influenza, looked at from the viewpoint of its natural reservoir - waterbirds. Our purpose here is to alert waterbird biologists that they have much to contribute to the science of this globally-important issue. New technologies have revealed that the genome of avian influenza contains much variation beyond that recognizable by classical antibody techniques, and have established avian influenza as a rapidly evolving and diversifying lineage. The extensive genetic variability in the viral genome and extensive reassortment within host species suggests that high pathogenicity could repeatedly and independently evolve from low pathogenic ancestors under appropriate selection pressures, such as those in poultry production systems. This makes infection of wild birds by HPAI lineages evolved in poultry a more likely occurrence than the reverse. The available evidence largely fits this model. We make recommendations that will help reduce the incursion of domestically-evolved avian influenza strains into wild populations of birds.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.192
Threshold uncertainty score0.574

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.060
GPT teacher head0.381
Teacher spread0.322 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it